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. 2017 Oct 6;7(10):6938-6941.
doi: 10.1021/acscatal.7b02905. Epub 2017 Sep 13.

Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group

Kai Hong  1 , Hojoon Park  1 , Jin-Quan Yu  1
Affiliations

Methylene C(sp3)-H Arylation of Aliphatic Ketones Using a Transient Directing Group

Kai Hong et al. ACS Catal. .

Abstract

Palladium-catalyzed methylene β-C(sp3)-H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp3)-H bond activation.

Keywords: C–H activation; arylation; ketone; palladium; transient directing group; β-amino acid.

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Conflict of interest statement

Notes The authors declare no competing financial interest.

Figures

Scheme 1
Scheme 1
Pd(II)-Catalyzed C(sp3)–H Arylation Using a Transient Directing Group Strategy
See this image and copyright information in PMC

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