Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Oct 17;10(10):1187.
doi: 10.3390/ma10101187.

Bionic Design, Materials and Performance of Bone Tissue Scaffolds

Tong Wu  1   2 , Suihuai Yu  3   4 , Dengkai Chen  5   6 , Yanen Wang  7
Affiliations
Review

Bionic Design, Materials and Performance of Bone Tissue Scaffolds

Tong Wu et al. Materials (Basel). .

Abstract

Design, materials, and performance are important factors in the research of bone tissue scaffolds. This work briefly describes the bone scaffolds and their anatomic structure, as well as their biological and mechanical characteristics. Furthermore, we reviewed the characteristics of metal materials, inorganic materials, organic polymer materials, and composite materials. The importance of the bionic design in preoperative diagnosis models and customized bone scaffolds was also discussed, addressing both the bionic structure design (macro and micro structure) and the bionic performance design (mechanical performance and biological performance). Materials and performance are the two main problems in the development of customized bone scaffolds. Bionic design is an effective way to solve these problems, which could improve the clinical application of bone scaffolds, by creating a balance between mechanical performance and biological performance.

Keywords: bionic design; bone tissue scaffolds; materials; performance.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Bone tissue repairing process.
Figure 2
Figure 2
The anatomical structure of biological bone.
Figure 3
Figure 3
Hydroxyapatite/collagen composite’s application in repairing of bone defects. (a) Bone scaffolds of the hydroxyapatite/collagen composite; (b) Bone nails and bone plates of the hydroxyapatite/collagen composite.
Figure 4
Figure 4
Bionic design and manufacturing process of the inner microstructure of artificial bone scaffold.
See this image and copyright information in PMC

References

    1. Basu B., Katti D., Kumar A. Advanced Biomaterials: Fundamentals, Processing, and Applications. The American Ceramic Society; Westerville, OH, USA: 2010.
    1. Partridge K., Yang X., Clarke N.M., Okubo Y., Bessho K., Sebald W., Howdle S.M., Shakesheff K.M., Oreffo R.O. Adenoviral BMP-2 gene transfer in mesenchymal stem cells: In vitro and in vivo bone formation on biodegradable polymer scaffolds. Biochem. Biophys. Res. Commun. 2002;292:144–152. doi: 10.1006/bbrc.2002.6623. - DOI - PubMed
    1. Tang D., Tare R.S., Yang L.Y., Williams D.F., Ou K.L., Oreffo R.O. Biofabrication of bone tissue: Approaches, challenges and translation for bone regeneration. Biomaterials. 2016;83:363–382. doi: 10.1016/j.biomaterials.2016.01.024. - DOI - PubMed
    1. Mitra J., Tripathi G., Sharma A., Basu B. Scaffolds for bone tissue engineering: Role of surface patterning on osteoblast response. RSC Adv. 2013;3:11073–11094. doi: 10.1039/c3ra23315d. - DOI
    1. Kumar A., Mandal S., Barui S., Vasireddi R., Gbureck U., Gelinsky M., Basu B. Low temperature additive manufacturing of three dimensional scaffolds for bone-tissue engineering applications: Processing related challenges and property assessment. Mater. Sci. Eng. R. 2016;103:1–39. doi: 10.1016/j.mser.2016.01.001. - DOI