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. 2017 Nov-Dec;43(6):1152-1159.
doi: 10.1590/S1677-5538.IBJU.2016.0548.

Transition to adulthood with a bladder augmentation: histopathologic concerns

Emil Mammadov  1 , Sergulen Dervisoglu  2 , Mehmet Elicevik  3 , Haluk Emir  3 , Yunus Soylet  3 , S N Cenk Buyukunal  3
Affiliations

Transition to adulthood with a bladder augmentation: histopathologic concerns

Emil Mammadov et al. Int Braz J Urol. 2017 Nov-Dec.

Abstract

Aim: To investigate the histopathologic changes in native bladder and gastrointestinal segment, the relation between histopathologic changes, type of operation and the period passed over operation in patients with bladder augmentation.

Materials and methods: Twenty consecutive patients were enrolled in this study. Histopathologic evaluation of the cystoscopic mucosal biopsies from native bladder and enteric augment was performed in all patients.

Results: Active or chronic non-specific inflammation of various degrees was found in all specimens except two. Metaplastic changes were detected in 3 patients. Two patients had squamous metaplasia (one focal, one extensive) and one patient had intestinal metaplasia. All metaplastic changes were found in native bladder specimens. The type of augmentation in patients with metaplastic changes were ileocystoplasty and sigmoidocystoplasty. No signs of malignancy were detected in any patient.

Conclusion: The complexity of the disorders requiring bladder augmentation does not let the surgeons to draw a clear line between different groups of complications including malignancy formation. However, due to challenging course of the augmentation procedure itself, surgeons should be well aware of the possibility of malignancy development.

Keywords: Neoplasms; Pediatrics; Urinary Bladder.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1. Planned sites for biopsies (triangular manner).
Figure 2
Figure 2. Focal intestinal metaplasia (H-E staining, 200 magnification).
See this image and copyright information in PMC

Comment in

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