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. 2017 Nov 27;216(9):1159-1163.
doi: 10.1093/infdis/jix460.

Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome

Varghese George  1 , Linda Harrison  2 , Margaret Roach  1 , Xiao-Dong Li  3 , Camlin Tierney  2 , Margaret A Fischl  4 , Judith Aberg  5 , Pablo Tebas  6 , David M Asmuth  3 , Richard B Pollard  3 , Catherine Godfrey  7 , Savita Pahwa  1 ; AIDS Clinical Trials Group A5202 Study Team
Affiliations

Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome

Varghese George et al. J Infect Dis. .

Abstract

A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.

Keywords: IRIS; cytokines; immune reconstitution inflammatory syndrome; microbial translocation.

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Figures

Figure 1.
Figure 1.
Baseline biomarkers by immune reconstitution inflammatory syndrome (IRIS) status. Circulating levels of chemokines (CCL2 and CXCL10) and cytokines (interferon [IFN] α2) (A), immune activation (soluble CD14), and markers of microbial translocation (16S ribosomal DNA [rDNA] and lipopolysaccharide [LPS]) (B) were quantitated in plasma from IRIS cases and controls. Biomarkers with significant (P < .05) associations confirmed by adjusted models are displayed. *P values from unadjusted models are given. Black lines display the median and intertertile range (33rd, 67th percentile). Dashed line displays detection limit, the highest lower limit of all runs.
See this image and copyright information in PMC

References

    1. Walker NF, Scriven J, Meintjes G, Wilkinson RJ. Immune reconstitution inflammatory syndrome in HIV-infected patients. HIV AIDS (Auckl) 2015; 7:49–64. - PMC - PubMed
    1. Jiang W, Lederman MM, Hunt P et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis 2009; 199:1177–85. - PMC - PubMed
    1. Pilakka-Kanthikeel S, Huang S, Fenton T, Borkowsky W, Cunningham CK, Pahwa S. Increased gut microbial translocation in HIV-infected children persists in virologic responders and virologic failures after antiretroviral therapy. Pediatr Infect Dis J 2012; 31:583–91. - PMC - PubMed
    1. Haddow LJ, Dibben O, Moosa MY, Borrow P, Easterbrook PJ. Circulating inflammatory biomarkers can predict and characterize tuberculosis-associated immune reconstitution inflammatory syndrome. AIDS 2011; 25:1163–74. - PubMed
    1. Goovaerts O, Jennes W, Massinga-Loembé M et al. TB-IRIS Study Group LPS-binding protein and IL-6 mark paradoxical tuberculosis immune reconstitution inflammatory syndrome in HIV patients. PLoS One 2013; 8:e81856. - PMC - PubMed

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