Comparative Study
doi: 10.1002/mds.870020106.
Antiparkinsonian activity of a single oral dose of PHNO
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- PMID: 2904120
- DOI: 10.1002/mds.870020106
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Comparative Study
Antiparkinsonian activity of a single oral dose of PHNO
Mov Disord.
1987.
Abstract
PHNO, a new D-2 agonist, was investigated in five patients with Parkinson's disease. In an acute, open, oral, dose-ranging study comparing benefit from single doses, 4 mg of PHNO was found to be equivalent to one tablet of Sinemet 25/250 mg. Adverse reactions were those anticipated for a dopaminomimetic agent. Because of its novel structure and apparent transcutaneous penetration, further studies on PHNO are desirable.
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