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. 2018 Jan;155(1):1-7.e1.
doi: 10.1016/j.jtcvs.2017.08.137. Epub 2017 Sep 19.

Limited root repair in acute type A aortic dissection is safe but results in increased risk of reoperation

Peter Chiu  1 , Jeffrey Trojan  2 , Sarah Tsou  2 , Andrew B Goldstone  1 , Y Joseph Woo  2 , Michael P Fischbein  3
Affiliations

Limited root repair in acute type A aortic dissection is safe but results in increased risk of reoperation

Peter Chiu et al. J Thorac Cardiovasc Surg. 2018 Jan.

Abstract

Objective: Management of the aortic root is a challenge for surgeons treating acute type A aortic dissection.

Methods: We performed a retrospective review of the acute type A aortic dissection experience at Stanford Hospital between 2005 and 2015 and identified patients who underwent either limited root repair or aortic root replacement. Differences in baseline characteristics were balanced with inverse probability weighting to estimate the average treatment effect on the controls. Weighted logistic regression was used to evaluate in-hospital mortality. Weighted Cox proportional hazards regression was used to evaluate differences in the hazard for mid-term death. Reoperation was evaluated with death as a competing risk with the Fine-Gray subdistribution hazard.

Results: After we excluded patients managed either nonoperatively or with definitive endovascular repair, there were 293 patients without connective tissue disease who underwent either limited root repair or aortic root replacement. There was no difference in weighted perioperative mortality, odds ratio 0.89 (95% confidence interval [CI], 0.44-1.76, P = .7), and there was no difference in weighted survival, hazard ratio 1.12 (95% CI, 0.54-2.31, P = .8). Risk of reoperation was greater in limited root repair (11.8%, 95% CI, 0.0%-23.8%) than for root replacement (0%), P < .001.

Conclusions: Limited root repair was associated with increased risk of late reoperation after repair of acute type A aortic dissection. Surgeons with adequate experience may consider aortic root replacement in well-selected patients. However, given good outcomes after limited root repair, surgeons should not feel compelled to perform this more-complex operation.

Keywords: aorta; aortic dissection; aortic root repair; aortic root replacement; outcomes; reoperation.

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Conflict of interest statement

Potential Conflicts of Interest: The other authors report no potential conflicts of interest.

Figures

Figure 1
Figure 1
Adjusted survival curves comparing limited root repair (blue) with aortic root replacement (red). Shading represents 95% confidence intervals. There was no significant difference in mid-term survival between the approaches.
Figure 2
Figure 2
Risk of reoperation, with death as a competing risk, comparing limited root repair (blue) with aortic root replacement (red). Shading represents 95% confidence intervals. Limited root repair was associated with an increased risk of reoperation.
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References

    1. Pape LA, Awais M, Woznicki EM, et al. Presentation, Diagnosis, and Outcomes of Acute Aortic Dissection: 17-Year Trends From the International Registry of Acute Aortic Dissection. Journal of the American College of Cardiology. 2015 Jul 28;66(4):350–358. - PubMed
    1. Bavaria JE, Pochettino A, Brinster DR, et al. New paradigms and improved results for the surgical treatment of acute type A dissection. Annals of surgery. 2001 Sep;234(3):336–342. discussion 342-333. - PMC - PubMed
    1. Andersen ND, Ganapathi AM, Hanna JM, Williams JB, Gaca JG, Hughes GC. Outcomes of acute type a dissection repair before and after implementation of a multidisciplinary thoracic aortic surgery program. Journal of the American College of Cardiology. 2014 May 6;63(17):1796–1803. - PMC - PubMed
    1. Rylski B, Bavaria JE, Milewski RK, et al. Long-term results of neomedia sinus valsalva repair in 489 patients with type A aortic dissection. The Annals of thoracic surgery. 2014 Aug;98(2):582–588. discussion 588-589. - PubMed
    1. Wang Z, Greason KL, Pochettino A, et al. Long-term outcomes of survival and freedom from reoperation on the aortic root or valve after surgery for acute ascending aorta dissection. The Journal of thoracic and cardiovascular surgery. 2014 Nov;148(5):2117–2122. - PubMed

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