Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct 5:13:44.
doi: 10.1186/s13223-017-0216-7. eCollection 2017.

Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population

Ping Li #  1 , Zhongjuan Liu #  2 , Ziyan Wu  1 , Xiaoting Wen  1 , Liubing Li  1 , Shulan Zhang  1 , Yingchun Xu  2 , Yongzhe Li  1
Affiliations

Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population

Ping Li et al. Allergy Asthma Clin Immunol. .

Abstract

Objective: To determine the adult reference intervals for the Siemens IgG subclass reagents.

Methods: 636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits.

Results: IgGSc reference intervals were as follows: IgG1 4.45-9.76 g/L, IgG2 2.07-8.57 g/L, IgG3 0.08-0.80 g/L and IgG4 0.05-1.54 g/L. There was an excellent correlation between the total IgG and the sum of the IgG subclasses. No significant gender and age differences were observed.

Conclusions: Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. The study can offer reference on clinic diagnose.

Keywords: Chinese population; Immunoglobulin subclasses; Immunonephelometric assays.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Histogram of square-root transformed IgG subclasses serum concentrations in 636 healthy adults
Fig. 2
Fig. 2
The relationship between total IgG and the sum of the IgG subclasses
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Gery HM, Kunkel HG. H chain subgroups of myeloma proteins and normal 7S gamma-globulin. J Exp Med. 1964;120:253–266. doi: 10.1084/jem.120.2.253. - DOI - PMC - PubMed
    1. Ballieux RE, Bernier GM, Tominaga K, Putnam FW. g-Globulin antigenic types defined by heavy chain determinants. Science. 1964;145(3628):168–170. doi: 10.1126/science.145.3628.168. - DOI - PubMed
    1. Schauer U, Stemberg F, Rieger CH, Borte M, Schubert S, Riedel F, et al. IgG subclass concentrations in certified reference material 470 and reference values for children and adults determined with the binding site reagents. Clin Chem. 2003;49(11):1924–1929. doi: 10.1373/clinchem.2003.022350. - DOI - PubMed
    1. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD) Mod Rheumatol. 2012;22(1):21–30. doi: 10.3109/s10165-011-0571-z. - DOI - PubMed
    1. Bonilla FA, Bernstein IL, Khan DA, Ballas ZK, Chinen J, Frank MM, et al. Practice parameters for the diagnosis and management of primary immunodeficiency. Ann Allergy Asthma Immunol. 2005;94(5):S1–S63. doi: 10.1016/S1081-1206(10)61142-8. - DOI - PubMed

LinkOut - more resources