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. 2017 Oct 5:13:44.
doi: 10.1186/s13223-017-0216-7. eCollection 2017.

Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population

Ping Li #  1 , Zhongjuan Liu #  2 , Ziyan Wu  1 , Xiaoting Wen  1 , Liubing Li  1 , Shulan Zhang  1 , Yingchun Xu  2 , Yongzhe Li  1
Affiliations

Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population

Ping Li et al. Allergy Asthma Clin Immunol. .

Abstract

Objective: To determine the adult reference intervals for the Siemens IgG subclass reagents.

Methods: 636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits.

Results: IgGSc reference intervals were as follows: IgG1 4.45-9.76 g/L, IgG2 2.07-8.57 g/L, IgG3 0.08-0.80 g/L and IgG4 0.05-1.54 g/L. There was an excellent correlation between the total IgG and the sum of the IgG subclasses. No significant gender and age differences were observed.

Conclusions: Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. The study can offer reference on clinic diagnose.

Keywords: Chinese population; Immunoglobulin subclasses; Immunonephelometric assays.

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Figures

Fig. 1
Fig. 1
Histogram of square-root transformed IgG subclasses serum concentrations in 636 healthy adults
Fig. 2
Fig. 2
The relationship between total IgG and the sum of the IgG subclasses
See this image and copyright information in PMC

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