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. 2017 Oct;14(4):3563-3568.
doi: 10.3892/etm.2017.4960. Epub 2017 Aug 18.

The efficacy of radiofrequency ablation in the treatment of pediatric arrhythmia and its effects on serum IL-6 and hs-CRP

Chunli Li  1 , Libo Jia  1 , Zhenzhou Wang  1 , Ling Niu  1 , Xinjiang An  1
Affiliations

The efficacy of radiofrequency ablation in the treatment of pediatric arrhythmia and its effects on serum IL-6 and hs-CRP

Chunli Li et al. Exp Ther Med. 2017 Oct.

Abstract

The aim of this study was to investigate the efficacy of radiofrequency ablation in the treatment of pediatric arrhythmia and to assess the changes in serum interleukin-6 (IL-6) and hs-CRP levels after treatment. Hundred and six children with tachyarrhythmia who were admitted to Xuzhou Children's Hospital from November, 2014 to December, 2015 were recruited for study. The efficacies of radiofrequency in the treatment of different types of arrhythmia were analyzed. Successful ablation was found in 104 cases (98.11%) and recurrence was found in 7 cases (6.73%). Among 62 cases of atrioventricular reentrant tachycardia (AVRT), successful ablation was found in 60 cases (96.77%) and recurrence was found in 3 cases (4.84%). Among 33 cases of atrioventricular nodal reentrant tachycardia (AVNRT), successful ablation was found in 33 cases (100%) and recurrence was found in 2 cases (6.06%). Among 5 cases of ventricular tachycardia (VT), successful ablation was found in 5 cases (100%) and no recurrence was found. Among 4 cases of atrial tachycardia (AT), successful ablation was found in 4 cases (100%) and recurrence was found in 1 case (25%). Among 2 cases of atrial flutter (AFL), successful ablation was found in both (100%) and recurrence was found in 1 case (50%). After operation, the levels of IL-6 and hs-CRP were increased and were continually increased within 6 h after operation. The levels of IL-6 and hs-CRP at 24 h after operation were reduced but still higher than preoperative levels. The duration of radiofrequency and ablation energy were positively correlated with the levels of IL-6 and hs-CRP, while the number of discharges was not significantly correlated with either. In conclusion, radiofrequency ablation is a safe and effective treatment for pediatric arrhythmia. Postoperative monitoring of IL-6 and hs-CRP levels is conducive to understanding postoperative myocardial injury and inflammatory response.

Keywords: pediatric arrhythmia; radiofrequency ablation.

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Figures

Figure 1.
Figure 1.
The changes in interleukin-6 (IL-6) levels after operation. Enzyme-linked immunosorbent assay (ELISA) results showed that the level of IL-6 was increased and was continually increased within 6 h after operation. The level of IL-6 at 24 h after the operation was still higher than the preoperative levels.
Figure 2.
Figure 2.
The changes in Hs-CRP levels after operation. Biochemical analysis showed that the level of Hs-CRP was increased and was continually increased within 6 h after operation. The level of Hs-CRP at 24 h after operation was still higher than the preoperative levels.
See this image and copyright information in PMC

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