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Case Reports
. 2016 Apr 29:4:5-10.
doi: 10.5414/CNCS108666. eCollection 2016.

Crescentic glomerulonephritis with dual positive anti-GBM and C-ANCA/PR3 antibodies

Bolanle A Omotoso  1   2 , Helen P Cathro  3 , Rasheed A Balogun  1
Affiliations
Case Reports

Crescentic glomerulonephritis with dual positive anti-GBM and C-ANCA/PR3 antibodies

Bolanle A Omotoso et al. Clin Nephrol Case Stud. .

Abstract

Antiglomerular basement membrane (anti-GBM) antibodies are more often accompanied by myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) than by proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA). Both disease processes can affect the kidneys and/or the lungs. Patients with dual positive disease may have an atypical presentation which may delay diagnosis and treatment. Here we report a case of crescentic glomerulonephritis associated with positive PR3-ANCA and anti-GBM antibodies who underwent both lung and kidney biopsies.

Keywords: ANCA-associated vasculitis; antiglomerular basement membrane antibody disease; crescentic GN.

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Figures

Figure 1.
Figure 1.. Glomerulus showing a cellular crescent with fibrinoid necrosis (Jones methenamine silver stain × 200).
Figure 2.
Figure 2.. Obsolescent glomerulus with adjacent multinucleated giant cell (H & E × 200).
Figure 3.
Figure 3.. Bright linear IgG staining of the glomerular capillary loops on immunofluorescence.
Figure 4.
Figure 4.. Necrotizing arteritis with transmural inflammation in the lung instertitium (H & E × 200).
Figure 5.
Figure 5.. Multinucleated giant cells in the lung (H & E × 400).
See this image and copyright information in PMC

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