Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jul-Aug;2(4):232-8.
doi: 10.1016/0920-1211(88)90013-7.

Suppression of ictal-like activity by kynurenic acid does not correlate with its efficacy as an NMDA receptor antagonist

R J Brady  1 , J W Swann
Affiliations

Suppression of ictal-like activity by kynurenic acid does not correlate with its efficacy as an NMDA receptor antagonist

R J Brady et al. Epilepsy Res. 1988 Jul-Aug.

Abstract

The involvement of excitatory amino acid (EAA) receptors in ictal-like activity was investigated using hippocampal slices from immature rats. Bath application of kynurenic acid (KYN) suppressed penicillin-induced synchronized afterdischarges. An identical concentration of D(-)2-amino-5-phosphonovaleric acid (D(-)AP5) spared the afterdischarges. Intracellular recordings confirmed D(-)AP5 to be the more potent N-methyl-D-aspartate antagonist. KYN's suppression of afterdischarges could not be clearly attributed to blockade of either kainate or quisqualate receptors. Thus, a novel kynurenate-preferring EAA receptor may play an important role in seizure generation in immature hippocampus.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources