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Case Reports
. 2018 Feb 28;12(3):376-378.
doi: 10.1093/ecco-jcc/jjx141.

Ustekinumab Drug Levels in Maternal and Cord Blood in a Woman With Crohn's Disease Treated Until 33 Weeks of Gestation

Catherine R Rowan  1 , Garret Cullen  1 , Hugh E Mulcahy  1 , Denise Keegan  1 , Kathryn Byrne  1 , Deirdre J Murphy  2 , Juliette Sheridan  1 , Glen A Doherty  1
Affiliations
Case Reports

Ustekinumab Drug Levels in Maternal and Cord Blood in a Woman With Crohn's Disease Treated Until 33 Weeks of Gestation

Catherine R Rowan et al. J Crohns Colitis. .

Abstract

A 35-year old woman with ileocolonic, perianal, and vulval Crohn's disease was treated with subcutaneous ustekinuamb [USK] throughout pregnancy. Dose intervals were shortened from 6-weekly to 4-weekly to maintain clinical remission. The last dose of USK was administered at 33 weeks of gestation, and a healthy baby boy was delivered by caesarean section at 37 weeks. Maternal trough USK levels remained stable during pregnancy. Cord blood USK levels were nearly 2-fold higher than contemporaneous maternal serum levels. To our knowledge, this is the first report of maternal and cord USK levels in a patient with Crohn's disease.

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