HIV-1 Latency by Transition

Boris Julg¹, Dan H Barouch²

Affiliations

¹ Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
² Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address: dbarouch@bidmc.harvard.edu.

PMID: 29045893
DOI: 10.1016/j.immuni.2017.09.019

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HIV-1 Latency by Transition

Boris Julg et al. Immunity. 2017.

Free article

. 2017 Oct 17;47(4):611-612.

doi: 10.1016/j.immuni.2017.09.019.

Authors

Boris Julg¹, Dan H Barouch²

Affiliations

¹ Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
² Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address: dbarouch@bidmc.harvard.edu.

PMID: 29045893
DOI: 10.1016/j.immuni.2017.09.019

Abstract

The latent HIV-1 reservoir represents the major barrier for the development of an HIV-1 cure. In this issue of Immunity, Shan et al. (2017) highlight that effector-to-memory transitioning (EMT) CD4⁺ T cells are particularly permissive for the establishment of latent HIV-1 infection.

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Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4⁺ T Cells Permissive for Latent HIV-1 Infection.
Shan L, Deng K, Gao H, Xing S, Capoferri AA, Durand CM, Rabi SA, Laird GM, Kim M, Hosmane NN, Yang HC, Zhang H, Margolick JB, Li L, Cai W, Ke R, Flavell RA, Siliciano JD, Siliciano RF. Shan L, et al. Immunity. 2017 Oct 17;47(4):766-775.e3. doi: 10.1016/j.immuni.2017.09.014. Immunity. 2017. PMID: 29045905 Free PMC article.

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K08 AI106408/AI/NIAID NIH HHS/United States

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HIV-1 Latency by Transition

Affiliations

HIV-1 Latency by Transition

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials