cGAS Micro-Manages Genotoxic Stress

Mona Motwani¹, Katherine A Fitzgerald²

Affiliations

¹ Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
² Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: kate.fitzgerald@umassmed.edu.

PMID: 29045895
DOI: 10.1016/j.immuni.2017.09.020

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cGAS Micro-Manages Genotoxic Stress

Mona Motwani et al. Immunity. 2017.

Free article

. 2017 Oct 17;47(4):616-617.

doi: 10.1016/j.immuni.2017.09.020.

Authors

Mona Motwani¹, Katherine A Fitzgerald²

Affiliations

¹ Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
² Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: kate.fitzgerald@umassmed.edu.

PMID: 29045895
DOI: 10.1016/j.immuni.2017.09.020

Abstract

Maintenance of genome integrity is essential to prevent cancer. Genotoxic stress drives damaged DNA out of the nucleus by forming micronuclei. Two studies in Nature reveal how the cytosolic DNA sensor cGAS gains access to the cargo within micronuclei to drive type I IFN responses.

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cGAS surveillance of micronuclei links genome instability to innate immunity.
Mackenzie KJ, Carroll P, Martin CA, Murina O, Fluteau A, Simpson DJ, Olova N, Sutcliffe H, Rainger JK, Leitch A, Osborn RT, Wheeler AP, Nowotny M, Gilbert N, Chandra T, Reijns MAM, Jackson AP. Mackenzie KJ, et al. Nature. 2017 Aug 24;548(7668):461-465. doi: 10.1038/nature23449. Epub 2017 Jul 24. Nature. 2017. PMID: 28738408 Free PMC article.
Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA. Harding SM, et al. Nature. 2017 Aug 24;548(7668):466-470. doi: 10.1038/nature23470. Epub 2017 Jul 31. Nature. 2017. PMID: 28759889 Free PMC article.

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cGAS Micro-Manages Genotoxic Stress

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cGAS Micro-Manages Genotoxic Stress

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Abstract

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