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Comparative Study
. 1988 Dec 8;336(6199):551-7.
doi: 10.1038/336551a0.

A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein

C Scheidereit  1 , J A Cromlish, T Gerster, K Kawakami, C G Balmaceda, R A Currie, R G Roeder
Affiliations
Comparative Study

A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein

C Scheidereit et al. Nature. .

Abstract

The human lymphoid-specific transcription factor OTF-2 contains a homoeodomain that is required for DNA binding and binds specifically to DNA elements that are recognized by Drosophila homoeodomain proteins, suggesting coevolutionary relationships between mammalian and invertebrate homoeodomain proteins and their DNA recognition elements.

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