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. 1988 Jul;40(7):512-3.
doi: 10.1111/j.2042-7158.1988.tb05289.x.

The effect of ciprofibrate on gastric secretion in the rat

C T Eason  1 , A Pattison, D D Howells, F W Bonner
Affiliations
Free article

The effect of ciprofibrate on gastric secretion in the rat

C T Eason et al. J Pharm Pharmacol. 1988 Jul.
Free article

Abstract

The potential of ciprofibrate to inhibit gastric secretion has been investigated in the rat. A significant gastric antisecretory effect was observed following a single oral administration of 300 and 500 mg kg-1 and following a single intraduodenal dose of 100, 300 and 500 mg kg-1. The toxicological significance of this finding is discussed in the light of a spate of recent publications linking changes in gastric morphology with hypergastrinaemia produced as a secondary effect of inhibition of acid secretion.

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