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. 2017 Jul 6;8(41):69709-69721.
doi: 10.18632/oncotarget.19068. eCollection 2017 Sep 19.

Ethnic heterogeneity and prostate cancer mortality in Hispanic/Latino men: a population-based study

Felix M Chinea  1   2 , Vivek N Patel  1   2 , Deukwoo Kwon  2 , Narottam Lamichhane  1   2 , Chris Lopez  1   2 , Sanoj Punnen  2   3 , Erin N Kobetz  2   4 , Matthew C Abramowitz  1   2 , Alan Pollack  1   2
Affiliations

Ethnic heterogeneity and prostate cancer mortality in Hispanic/Latino men: a population-based study

Felix M Chinea et al. Oncotarget. .

Abstract

Background: Few studies focus on prostate cancer (PCa) outcomes in Hispanic/Latino men. Our study explores whether Hispanic/Latino subgroups demonstrate significantly different prostate cancer-specific mortality (PCSM) relative to Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) men.

Methods: We extracted a population-based cohort of men diagnosed with local-regional PCa from 2000-2013 (n= 486,865). PCSM was measured in racial/ethnic groups: NHW (n=352,886), NHB (n= 70,983), Hispanic/Latino (n= 40,462), and Asian American/Pacific Islander (n= 22,534). PCSM was also measured in Hispanic/Latino subgroups: Mexican (n= 8,077), Puerto Rican (n= 1,284), South or Central American (n= 3,021), Cuban (n= 788), and Dominican (n= 300). We conducted univariable and multivariable analyses (MVA) to compare risk for PCSM.

Results: Compared to NHW men, results showed worse outcomes for NHB men with similar outcomes for Hispanic/Latino men. In MVA with NHW men as a reference, NHB (HR= 1.15, p <0.001) men had significantly worse PCSM and Hispanic/Latino (HR= 1.02, p= 0.534) men did not show a significant difference. In a second MVA, Puerto Rican (HR= 1.71, p <0.001) and Mexican (HR= 1.21, p= 0.008) men had significantly higher PCSM. With NHB men as a reference, the MVA showed Puerto Rican (HR= 1.50, p= 0.006) men with higher PCSM and Mexican (HR= 1.08, p= 0.307) men with no significant difference.

Conclusions: Our findings indicate previously unknown disparities in PCSM for Puerto Rican and Mexican American men.

Keywords: Hispanic/Latino; cancer specific mortality; health disparities; minority health; prostate cancer.

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Conflict of interest statement

CONFLICTS OF INTEREST All authors had no conflicts of interest related to this study.

Figures

Figure 1
Figure 1
Cumulative incidence of prostate cancer-specific mortality in years divided by race and/or ethnicity: (left) Non-Hispanic White (black), Non-Hispanic Black (red), Hispanic/Latino (green), and Asian American/Pacific Islander (blue); (right) Non-Hispanic White (black), non-Hispanic Black (red), Asian American/Pacific Islander (blue), Mexican American (cyan), Puerto Rican (purple), Cuban (yellow), South or Central American excluding Brazil (grey), and Dominican Republic (green).
See this image and copyright information in PMC

References

    1. Ries L, Hankey B, Kosary C, Harras A, Edwards B. SEER Cancer Statistics Review, 1973-1991: Tables and Graphs, National Cancer Institute. NIH Publication no. 94-2789. 1994.
    1. Mahal BA, Ziehr DR, Aizer AA, Hyatt AS, Sammon JD, Schmid M, Choueiri TK, Hu JC, Sweeney CJ, Beard CJ, D'Amico AV, Martin NE, Lathan C, et al. Getting back to equal: The influence of insurance status on racial disparities in the treatment of African American men with high-risk prostate cancer. Urologic oncology. 2014;32:1285–1291. - PubMed
    1. Mahal BA, Aizer AA, Ziehr DR, Hyatt AS, Sammon JD, Schmid M, Choueiri TK, Hu JC, Sweeney CJ, Beard CJ, D'Amico AV, Martin NE, Kim SP, et al. Trends in disparate treatment of African American men with localized prostate cancer across National Comprehensive Cancer Network risk groups. Urology. 2014;84:386–392. - PubMed
    1. Kryvenko ON, Balise R, Soodana Prakash N, Epstein JI. African-American Men with Gleason Score 3+3=6 Prostate Cancer Produce Less Prostate Specific Antigen than Caucasian Men: A Potential Impact on Active Surveillance. J Urol. 2016;195:301–306. - PubMed
    1. Sundi D, Kryvenko ON, Carter HB, Ross AE, Epstein JI, Schaeffer EM. Pathological examination of radical prostatectomy specimens in men with very low risk disease at biopsy reveals distinct zonal distribution of cancer in black American men. J Urol. 2014;191:60–67. - PMC - PubMed

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