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Review
. 2018 Apr-Jun;12(2):189-194.
doi: 10.1016/j.dsx.2017.09.007. Epub 2017 Sep 21.

Platelet rich plasma and growth factors cocktails for diabetic foot ulcers treatment: State of art developments and future prospects

I V Gonchar  1 , A R Lipunov  2 , I M Afanasov  3 , V Larina  4 , A P Faller  4 , A V Kibardin  5
Affiliations
Review

Platelet rich plasma and growth factors cocktails for diabetic foot ulcers treatment: State of art developments and future prospects

I V Gonchar et al. Diabetes Metab Syndr. 2018 Apr-Jun.

Abstract

Current advances in diabetic foot ulcers (DFU) treatment are discussed. Normal and pathological wound healing process are observed and the role of growth factors (GFs) is elucidated. Current techniques involving GFs and platelet rich plasma (PRP) are compared. Up-to-date research suggests that treatment with single growth factor (GF) could be insufficient and not encompassing all pathological changes in DFU bed. Efficiency of PRP is rather controversial and lacks evidence. Thus the use of cocktail of particular GFs is suggested. Pro et contra of each approach are discussed.

Keywords: Diabetes; Diabetic foot ulcer; Growth factors; Growth factors cocktail; Platelet rich plasma.

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