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. 2017 Oct 10;5(4):2324709617734245.
doi: 10.1177/2324709617734245. eCollection 2017 Oct-Dec.

Autoimmune Pancreatitis Type 2: Case Report

Chidinma Onweni  1 , Harika Balagoni  1 , Jennifer M Treece  1 , Emmanuel Addo Yobo  1 , Archi Patel  1 , Jennifer Phemister  1   2 , Manoj Srinath  1   2 , Mark F Young  1   2
Affiliations

Autoimmune Pancreatitis Type 2: Case Report

Chidinma Onweni et al. J Investig Med High Impact Case Rep. .

Abstract

A middle-aged man presents with acute pancreatitis of unknown etiology and is found to have a presentation consistent with the diagnosis of type 2 autoimmune pancreatitis (AIP). AIP is a group of rare heterogeneous diseases that are challenging to diagnose. There are 2 types of AIP. Type 1 disease is the more common worldwide than type 2 AIP. While type 1 AIP is associated with IgG4-positive antibodies, type 2 AIP is IgG4 antibody negative. Both types of AIP are responsive to corticosteroid treatment. Although type 1 AIP has more extrapancreatic manifestations and more commonly relapses, this is a case of a patient with type 2 AIP with inflammatory bowel disease and relapsing course.

Keywords: IgG4 antibody; IgG4-related disease; autoimmune pancreatitis; chronic pancreatitis; corticosteroid therapy; lymphoplasmacytic sclerosing pancreatitis; type 1; type 2.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Rectosigmoid colon, biopsy: Acute and chronic inflammation, cryptitis, crypt abscesses, crypt distortion, and crypt drop-out. Focal surface ulceration is also noted on the colon biopsy, showing infiltrates consistent with colitis. No dysplasia identified.
See this image and copyright information in PMC

References

    1. Takita M, Itoh T, Matsumoto S, et al. Autoimmune chronic pancreatitis with IgG4-related pancreatic pseudocyst in a patient undergoing total pancreatectomy followed by autologous islet transplantation: a case report. Pancreas. 2013;42:175-177. doi: 10.1097/MPA.0b013e3182546e37. - DOI - PMC - PubMed
    1. Sugumar A, Chari S. Autoimmune pancreatitis: an update. Expert Rev Gastroenterol Hepatol. 2009;3:197-204. - PubMed
    1. Ketwaroo GA, Sheth S. Autoimmune pancreatitis. Gastroenterol Rep (Oxf). 2013;1:27-32. doi: 10.1093/gastro/got011. - DOI - PMC - PubMed
    1. Detlefsen S, Löhr M, Drewes AM, Frøkjær JB, Klöppel G. Current concepts in the diagnosis and treatment of type 1 and type 2 autoimmune pancreatitis. Recent Pat Inflamm Allergy Drug Discov. 2011;5:136-149. - PubMed
    1. Notohara K, Nishimori I, Mizuno N, et al. Clinicopathological features of type 2 autoimmune pancreatitis in Japan: results in a multicenter survey. Pancreas. 2015;44:1072-1077. - PubMed

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