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. 2017 Nov 1;75(11):920-933.
doi: 10.1093/nutrit/nux044.

Systematic review of the concentrations of oligosaccharides in human milk

Stephan Thurl  1 , Manfred Munzert  2 , Günther Boehm  3 , Catherine Matthews  4 , Bernd Stahl  5
Affiliations

Systematic review of the concentrations of oligosaccharides in human milk

Stephan Thurl et al. Nutr Rev. .

Abstract

Context: Oligosaccharides are the third largest solid component in human milk. These diverse compounds are thought to have numerous beneficial functions in infants, including protection against infectious diseases. The structures of more than 100 oligosaccharides in human milk have been elucidated so far.

Objective: The aim of this review was to identify the main factors that affect the concentrations of oligosaccharides in human milk and to determine whether it is possible to calculate representative and reliable mean concentrations.

Data sources: A comprehensive literature search on oligosaccharide concentrations in human milk was performed in 6 electronic databases: BIOSIS, Current Contents Search, Embase, Lancet Titles, MEDLINE and PubMed.

Study selection: The initial search resulted in 1363 hits. After the elimination of duplicates, the literature was screened. The application of strict inclusion criteria resulted in 21 articles selected.

Data extraction: Oligosaccharide concentrations, both mean values and single values, reported in the literature were sorted by gestational age, secretor status of mothers, and defined lactation periods.

Results: Mean concentrations, including confidence limits, of 33 neutral and acidic oligosaccharides reported could be calculated. Concentrations of oligosaccharides in human milk show variations that are dependent on both the secretor type of the mother and the lactation period as examined by analyses of variance. In addition, large interlaboratory variations in the data were observed.

Conclusions: Worldwide interlaboratory quantitative analyses of identical milk samples would be required to identify the most reliable methods of determining concentrations of oligosaccharides in human milk. The data presented here contribute to the current knowledge about the composition and quantities of oligosaccharides in human milk and may foster greater understanding of the biological functions of these compounds.

Keywords: concentration; human milk; lactation period; oligosaccharide; secretor status.

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Figures

Figure 1
Figure 1
Flow diagram of the literature search process.
Figure 2
Figure 2
Structures of the HMOS examined in this review. (A) Neutral HMOS, (B) acidic nonfucosylated HMOS, (C) acidic fucosylated HMOS, (D) monomers and linkages.
Figure 3
Figure 3
Comparison of neutral HMOS concentrations in milks from secretor and nonsecretor mothers.
Figure 4
Figure 4
Comparison of acidic HMOS concentrations in milks from secretor and nonsecretor mothers.
See this image and copyright information in PMC

References

    1. Urashima T, Asakuma S, Leo F. et al. The predominance of type I oligosaccharides is a feature specific to human breast milk. Adv Nutr. 2012;3:473S–482S. - PMC - PubMed
    1. Kobata A. Structures and functions of the sugar chains of glycoproteins. Eur J Biochem. 1992;209:483–501. - PubMed
    1. Kuhn R, Baer HH. Die Konstitution der Lacto-N-tetraose [in German]. Chem Ber. 1956;89:504–511.
    1. Montreuil J, Mullet S. Étude des variations des constituants glucidiques du lait de femme au cours de la lactation [in French]. Bull Soc Chim Biol (Paris). 1960;42:365–377. - PubMed
    1. Bruntz R, Dabrowski U, Dabrowski J. et al. Fucose-containing oligosaccharides from human milk from a donor of blood group 0 Lea nonsecretor. Biol Chem Hoppe Seyler. 1988;369:257–274. - PubMed

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