Comment
doi: 10.1016/j.molcel.2017.10.005.
Spt6 Gets in the Way of Polycomb to Promote ESC Pluripotency
Affiliations
- PMID: 29053954
- DOI: 10.1016/j.molcel.2017.10.005
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Comment
Spt6 Gets in the Way of Polycomb to Promote ESC Pluripotency
Mol Cell.
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Abstract
Despite expressing high levels of Polycomb group proteins, embryonic stem cells (ESCs) are refractory to H3K27 trimethylation, notably at super-enhancers regulating key pluripotency genes. In this issue of Molecular Cell, Wang et al. (2017) report that the histone chaperone Spt6 prevents H3K27 trimethylation of key ESC super-enhancers.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.Mol Cell. 2017 Oct 19;68(2):398-413.e6. doi: 10.1016/j.molcel.2017.09.016. Epub 2017 Oct 12. Mol Cell. 2017. PMID: 29033324 Free PMC article.