FUS Zigzags Its Way to Cross Beta
- PMID: 29053965
- DOI: 10.1016/j.cell.2017.10.007
FUS Zigzags Its Way to Cross Beta
Abstract
The low-complexity domain (LCD) of the FUS protein forms concentration-dependent assemblies, including liquid droplets and fibril-based hydrogels. The molecular structures of FUS within different assemblies and their functional relevance are subjects of intense debate. Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some questions and raises new ones.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains.Cell. 2017 Oct 19;171(3):615-627.e16. doi: 10.1016/j.cell.2017.08.048. Epub 2017 Sep 21. Cell. 2017. PMID: 28942918 Free PMC article.
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