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. 2017 Oct 19;171(3):499-500.
doi: 10.1016/j.cell.2017.10.007.

FUS Zigzags Its Way to Cross Beta

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FUS Zigzags Its Way to Cross Beta

Alex S Holehouse et al. Cell. .
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Abstract

The low-complexity domain (LCD) of the FUS protein forms concentration-dependent assemblies, including liquid droplets and fibril-based hydrogels. The molecular structures of FUS within different assemblies and their functional relevance are subjects of intense debate. Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some questions and raises new ones.

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