Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov;11(6):564-568.
doi: 10.1111/irv.12514.

Human parainfluenza virus infection in severe acute respiratory infection cases in Beijing, 2014-2016: A molecular epidemiological study

Yang Pan  1   2   3 , Yi Zhang  1   2 , Weixian Shi  1   2 , Xiaomin Peng  1   2 , Shujuan Cui  1   2 , Daitao Zhang  1   2 , Guilan Lu  1   2 , Yimeng Liu  1   2 , Shuangsheng Wu  1   2 , Peng Yang  1   2   3 , Quanyi Wang  1   2
Affiliations

Human parainfluenza virus infection in severe acute respiratory infection cases in Beijing, 2014-2016: A molecular epidemiological study

Yang Pan et al. Influenza Other Respir Viruses. 2017 Nov.

Abstract

Background: Severe acute respiratory infection (SARI) threatens human health and even survival, causing a huge number of hospitalized patients every year. However, as one of the most common respiratory viruses circulated worldwide, the epidemiological and phylogenetic characteristics of human parainfluenza virus (HPIV) in these cases were not well known.

Objectives: To reveal the epidemiological features of HPIV infection in SARIs in Beijing area from September 2014 to August 2016.

Methods: A total of 1229 SARI cases in Beijing area were enrolled, investigated, sampled, and tested by multiplex real-time PCR to identify HPIVs and other common respiratory viruses. Eighteen HPIV-3 viruses isolated from all HPIV-positive samples in these SARI cases were sequenced and analyzed.

Results: Among all enrolled cases, 0.81%, 0.73%, 4.48%, and 0.57% were positive for HPIV-1 to HPIV-4, respectively. The highest yield rate of HPIV infection occurred in children under 5 years old (9.07%), followed by the patients over 60 years old (6.02%). The phylogenetic information of HPIV-3 showed that all viruses belonged to Cluster C3a.

Conclusions: Besides the young children, the elders older than 60 years also showed a relatively high infection rate of HPIVs, which should be given comparable attentions. Moreover, the HPIV-3 circulating in China undergoes continued evolution, suggesting the potential risk of evolved HPIV infection should not be overlooked.

Keywords: hemagglutinin-neuraminidase; human parainfluenza virus; molecular epidemiology; phylogenetic analysis; severe acute respiratory infection; variation.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of the severe acute respiratory infections (SARIs) cases with human parainfluenza virus (HPIV) infection from September 2014 to August 2016
Figure 2
Figure 2
Phylogenetic analysis of hemagglutinin‐neuraminidase (HN) gene of human parainfluenza virus 3 from severe acute respiratory infection (SARI) cases. The phylogenetic trees were constructed using mega program and employing Neighbor‐joining (NJ) method with Kimura 2‐parameters substitution model and 1000 bootstraps. Only bootstrap number >70% is shown. ▲, ■, and ●, the viruses isolated in 2014, 2015, and 2016, respectively. *, The representative HN sequences in 2014‐2016 in Beijing
See this image and copyright information in PMC

References

    1. Henrickson KJ. Parainfluenza viruses. Clin Microbiol Rev. 2003;16:242‐264. - PMC - PubMed
    1. Hall CB. Respiratory syncytial virus and parainfluenza virus. N Engl J Med. 2001;344:1917‐1928. - PubMed
    1. Tsukagoshi H, Ishioka T, Noda M, et al. Molecular epidemiology of respiratory viruses in virus‐induced asthma. Front Microbiol. 2013;4:278. - PMC - PubMed
    1. Rosenthal LA, Avila PC, Heymann PW, et al. Viral respiratory tract infections and asthma: the course ahead. J Allergy Clin Immunol. 2010;125:1212‐1217. - PMC - PubMed
    1. Liu WK, Liu Q, Chen DH, et al. Epidemiology and clinical presentation of the four human parainfluenza virus types. BMC Infect Dis. 2013;13:28. - PMC - PubMed

Publication types

MeSH terms

Associated data

LinkOut - more resources