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Comment
. 2017 Nov 7;26(5):703-705.
doi: 10.1016/j.cmet.2017.09.022. Epub 2017 Oct 19.

CANTOS Ushers in a New Calculus of Inflammasome Targeting for Vascular Protection-and Maybe More

Subodh Verma  1 , Lawrence A Leiter  2 , Deepak L Bhatt  3
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Free article
Comment

CANTOS Ushers in a New Calculus of Inflammasome Targeting for Vascular Protection-and Maybe More

Subodh Verma et al. Cell Metab. .
Free article

Abstract

Despite overwhelming basic science linking inflammation to the pathobiology of atherothrombosis, the specific clinical evidence indicating cardiovascular benefits from anti-inflammatory pharmacotherapy has been lacking. The CANTOS trial (Ridker et al., 2017a) now provides the first largescale proof of concept that inflammasome targeting can reduce cardiovascular events-and, surprisingly, lung cancer.

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  • Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
    Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ; CANTOS Trial Group. Ridker PM, et al. N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. Epub 2017 Aug 27. N Engl J Med. 2017. PMID: 28845751 Clinical Trial.