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Review
. 2016 Sep 28;3(4):27.
doi: 10.3390/vetsci3040027.

Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling

Dana K Shaw  1 , Erin E McClure  2 , Xiaowei Wang  3 , Joao H F Pedra  4
Affiliations
Review

Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling

Dana K Shaw et al. Vet Sci. .

Abstract

In the face of an assault, host cells mount an immediate response orchestrated by innate immunity. Two of the best described innate immune signaling networks are the Toll- and the Nod-like receptor pathways. Extensive work has been done characterizing both signaling cascades with several recent advances on the forefront of inflammasome biology. In this review, we will discuss how more commonly-studied pathogens differ from tick-transmitted microbes in the context of Nod-like receptor signaling and inflammasome formation. Because pathogens transmitted by ticks have unique characteristics, we offer the opinion that these microbes can be used to uncover novel principles of Nod-like receptor biology.

Keywords: Nod-like receptors (NLR); tick-borne diseases; tick-borne pathogens.

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Conflict of interest statement

The authors declare no conflict of interest.

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