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Review
. 2018 May;20(5):570-575.
doi: 10.1007/s12094-017-1774-3. Epub 2017 Oct 20.

Ki67 targeted strategies for cancer therapy

C Yang  1 , J Zhang  1 , M Ding  1   2 , K Xu  1   2 , L Li  1 , L Mao  3   4 , J Zheng  5
Affiliations
Review

Ki67 targeted strategies for cancer therapy

C Yang et al. Clin Transl Oncol. 2018 May.

Abstract

Ki67 is a well-known proliferation marker for the evaluation of cell proliferation. Numerous studies have indicated that Ki67 index independently predicts cancer progression. Moreover, because Ki67 is highly expressed in malignant cells but almost could not be detected in normal cells, it has become a promising target for cancer therapy. In this review, we summarize recent advances in Ki67 targeted cancer therapy. In particular, we highlight recent development on the exploitation of Ki67 promoter to drive the expression of siRNAs or therapeutic genes in cancer cells specifically. The use of Ki67 as an attractive target opens a new avenue for cancer therapy.

Keywords: Gene therapy; Ki67; Proliferation; Renal cancer; Target therapy; siRNA.

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