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Practice Guideline
. 2018 Jan;20(1):16-21.
doi: 10.1007/s12094-017-1762-7. Epub 2017 Oct 20.

SEOM clinical guidelines for anaplastic gliomas (2017)

C Balañá  1 , M Alonso  2 , A Hernandez-Lain, A Hernandez #  3 , P Perez-Segura  4 , E Pineda  5 , A Ramos  3 , A R Sanchez  6 , P Teixidor  7 , E Verger  5 , M Benavides  8
Affiliations
Practice Guideline

SEOM clinical guidelines for anaplastic gliomas (2017)

C Balañá et al. Clin Transl Oncol. 2018 Jan.

Erratum in

Abstract

The SEOM/GEINO clinical guidelines provide recommendations for radiological, and molecular diagnosis, treatment and follow-up of adult patients with anaplastic gliomas (AG). We followed the 2016 WHO classification which specifies the major diagnostic/prognostic and predictive value of IDH1/IDH2 missense mutations and 1p/19q codeletions in AG. The diagnosis of anaplastic oligoastrocytoma is discouraged. Surgery, radiotherapy and chemotherapy with PCV or TMZ are the first-line standard of care for AG with slight modifications according to molecular variables. A multidisciplinary team is highly recommended in the management of these tumors.

Keywords: Anaplastic astrocytoma; Anaplastic glioma; Anaplastic oligodendroglioma.

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Conflict of interest statement

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Figures

Fig. 1
Fig. 1
Diagnostic algorithm anaplastic gliomas *It is recommended starting with immunochemistry for R132H-mutant IDH1 followed by IDH1 and IDH2 sequencing of the tumors that were negative for IR132H-mutant DH1 immunochemistry. **Characteristic but not necessary for diagnosis. ***Recommended to confirm the astrocytic subtype but not necessary for diagnosis. Usually performed with immunochemistry. ****Characteristic but not necessary for diagnosis. RT radiotherapy, PCV procarbazine, lomustine and vincristine, TMZ temozolomide, Mut mutated
See this image and copyright information in PMC

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