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. 2017 Oct 23;10(10):CD009430.
doi: 10.1002/14651858.CD009430.pub2.

Planned caesarean section versus planned vaginal birth for severe pre-eclampsia

Affiliations

Planned caesarean section versus planned vaginal birth for severe pre-eclampsia

Melania Mr Amorim et al. Cochrane Database Syst Rev. .

Abstract

Background: Pre-eclampsia is a very frequent complication of pregnancy, and anticipation of birth is often necessary. However, the best mode of giving birth remains to be established, although observational studies suggest better maternal and perinatal outcomes with vaginal birth.

Objectives: To assess the effects of a policy of planned caesarean section versus planned vaginal birth for women with severe pre-eclampsia on mortality and morbidity for mother and baby.

Search methods: We searched Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials.gov, the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (6 September 2017) and reference lists of retrieved studies.

Selection criteria: We planned to include all randomised trials of planned caesarean section versus planned vaginal birth for pregnant women with severe pre-eclampsia. Quasi-randomised and non-randomised studies are not eligible for inclusion in this review.The focus of this review is severe pre-eclampsia; studies of planned caesarean section versus planned vaginal birth in pregnant women with eclampsia are not eligible for inclusion.

Data collection and analysis: We identified no studies that met the inclusion criteria. We excluded two studies.

Main results: There are no included studies in this review.

Authors' conclusions: There is a lack of robust evidence from randomised controlled trials that can inform practice regarding planned caesarean section versus planned vaginal birth for women with severe pre-eclampsia. There is a need for high-quality randomised controlled trials to assess the short- and long-term effects of caesarean section and vaginal birth for these women and their babies.

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Conflict of interest statement

Melania MR Amorim: None known. Alex Sandro R Souza: None known. Leila Katz: None known.

Figures

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Study flow diagram.

Update of

References

References to studies excluded from this review

Seal 2012 {published data only}
    1. Seal SL, Ghosh D, Kamilya G, Mukherji J, Hazra A, Garain P. Does route of delivery affect maternal and perinatal outcome in women with eclampsia? A randomized controlled pilot study. American Journal of Obstetrics & Gynecology 2012;206(6):484.e1‐484.e7. - PubMed
Tukur 2007 {published data only}
    1. Tukur J, Umar NI, Khan N, Musa D. Comparison of emergency caesarean section to misoprostol induction for the delivery of antepartum eclamptic patients: a pilot study. Nigerian Journal of Medicine 2007;16:364‐7. - PubMed

Additional references

ACOG 2002
    1. ACOG Committee on Obstetric Practice. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. International Journal of Gynecology & Obstetrics 2002;77(1):67‐75. - PubMed
ACOG 2013
    1. American College of Obstetricians and Gynecologists. Hypertension in Pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstetrics and Gynecology 2013;122(5):1122‐31. - PubMed
Alanis 2008
    1. Alanis MC, Robinson CJ, Hulsey TC, Ebeling M, Johnson DD. Early‐onset severe preeclampsia: induction of labor vs elective cesarean delivery and neonatal outcomes. American Journal of Obstetrics and Gynecology 2008;199(3):262.e1‐262.e6. - PubMed
Amorim 2015
    1. Amorim MM, Katz L, Barros AS, Almeida TS, Souza AS, Faúndes A. Maternal outcomes according to mode of delivery in women with severe preeclampsia: a cohort study. Journal of Maternal‐Fetal & Neonatal Medicine 2015; Vol. 28, issue 6:654‐60. - PubMed
Blackwell 2001
    1. Blackwell SC, Redman ME, Tomlinson M, Landwehr JB Jr, Tuynman M, Gonik B, et al. Labor induction for the preterm severe pre‐eclamptic patient: is it worth the effort?. Journal of Maternal‐Fetal Medicine 2001;10(5):305‐11. - PubMed
Catanzarite 1991
    1. Catanzarite V, Quirk JG, Aisenbrey G. How do perinatologists manage preeclampsia?. American Journal of Perinatology 1991;8(1):7‐10. - PubMed
Coppage 2002
    1. Coppage KH, Polzin WJ. Severe preeclampsia and delivery outcomes: is immediate cesarean delivery beneficial?. American Journal of Obstetrics and Gynecology 2002;186(5):921‐3. - PubMed
Drife 2006
    1. Drife J. Mode of delivery in the early preterm infant (<28 weeks). BJOG: an international journal of obstetrics and gynaecology 2003;113(3):81‐5. - PubMed
Duley 2009
    1. Duley L. The global impact of pre‐eclampsia and eclampsia. Seminars in Perinatology 2009;33(3):130‐7. [DOI: 10.1053/j.semperi.2009.02.010] - DOI - PubMed
Duley 2010a
    1. Duley L, Gülmezoglu AM, Henderson‐Smart DJ, Chou D. Magnesium sulphate and other anticonvulsants for women with pre‐eclampsia. Cochrane Database of Systematic Reviews 2010, Issue 11. [DOI: 10.1002/14651858.CD000025.pub2] - DOI - PMC - PubMed
Duley 2010b
    1. Duley L, Henderson‐Smart DJ, Walker GJA, Chou D. Magnesium sulphate versus diazepam for eclampsia. Cochrane Database of Systematic Reviews 2010, Issue 12. [DOI: 10.1002/14651858.CD000127.pub2] - DOI - PMC - PubMed
Duley 2010c
    1. Duley L, Henderson‐Smart DJ, Chou D. Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database of Systematic Reviews 2010, Issue 10. [DOI: 10.1002/14651858.CD000128.pub2] - DOI - PubMed
Esteves‐Pereira 2016
    1. Esteves‐Pereira AP, Deneux‐Tharaux C, Nakamura‐Pereira M, Saucedo M, Bouvier‐Colle MH, Leal Mdo C. Caesarean delivery and postpartum maternal mortality: a population‐based case control study in Brazil. PLoS One 2016;11(4):e0153396. - PMC - PubMed
Goldenberg 2008
    1. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008;371(9606):75‐84. - PMC - PubMed
Higgins 2011
    1. Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.handbook.cochrane.org.
HYPITAT 2009
    1. Koopmans CM, Bijlenga D, Groen H, Vijgen SM, Aarnoudse JG, Bekedam DJ, et al. Induction of labour versus expectant monitoring for gestational hypertension or mild pre‐eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open‐label randomised controlled trial. Lancet 2009;374(9694):979‐88. - PubMed
HYPITAT II 2015
    1. Broekhuijsen K, Baaren GJ, Pampus MG, Ganzevoort W, Sikkema JM, Woiski MD, et al. HYPITAT‐II study group. Immediate delivery versus expectant monitoring for hypertensive disorders of pregnancy between 34 and 37 weeks of gestation (HYPITAT‐II): an open‐label, randomised controlled trial. Lancet 2015;385(9986):2492‐501. - PubMed
ISSHP 2014
    1. Tranquilli AL, Dekker G, Magee L, Roberts J, Sibai BM, Steyn W, et al. The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP. Pregnancy Hypertension 2014;4(2):97‐104. - PubMed
Jauniaux 2017
    1. Jauniaux E, Bhide A. Prenatal ultrasound diagnosis and outcome of placenta previa accreta after cesarean delivery: a systematic review and meta‐analysis. American Journal of Obstetrics and Gynecology 2017;217(1):27‐36. - PubMed
Kawakita 2017
    1. Kawakita T, Bowers K. Maternal and neonatal outcomes of induction of labor compared with planned cesarean delivery in women with preeclampsia at 34 weeks' gestation or longer. American Journal of Perinatology 2017 August 24 [Epub ahead of print];10:935‐40. [DOI: 10.1055/s-0037-1606185] - DOI - PubMed
Khan 2006
    1. Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Look P. WHO systematic review of causes of maternal deaths. Lancet 2006;367(9516):1066‐74. - PubMed
Kuklina 2009
    1. Kuklina EV, Ayala C, Callaghan WM. Hypertensive disorders and severe obstetric morbidity in the United States. Obstetrics & Gynecology 2009;113(6):1299‐306. - PubMed
Magee 2008
    1. Magee LA, Helewa M, Moutquin JM, Dadelszen P, for the Hypertension Guideline Committee. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. SOGC Clinical Practice Guideline, No. 206, March 2008. Journal of Obstetrics & Gynaecology Canada: JOGC 2008;30(Suppl 1):1‐48.
Mozurkewich 2009
    1. Mozurkewich E, Chilimigras J, Koepke E, Keeton K, King VJ. Indications for induction of labour:a best‐evidence review. BJOG: an international journal of obstetrics and gynaecology 2009;116(5):626‐36. - PubMed
Nassar 1998
    1. Nassar AH, Adra AM, Chakhtoura N, Gómez‐Marín O, Beydoun S. Severe preeclampsia remote from term: labor induction or elective cesarean delivery?. American Journal of Obstetrics and Gynecology 1998;179(5):1210‐3. - PubMed
NHBPEP 2000
    1. NHPBPE. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. American Journal of Obstetrics and Gynecology 2000;183(1):S1‐S22. - PubMed
NICE 2011
    1. National Collaborating Centre for Women's and Children's Health. Hypertension in Pregnancy: Diagnosis and Management. London: National Institution for Health and Clinical Escellence, 2011.
Noronha Neto 2010
    1. Noronha Neto C, Souza AS, Amorim MM. Evidence‐based treatment of preeclampsia [Tratamento da pré‐eclâmpsia de acordo com as evidências]. Revista Brasileira de Ginecologia e Obstetricia 2010;32(9):459‐68. - PubMed
Norwitz 2017
    1. Norwitz ER. Preeclampsia: management and prognosis. Uptodate 2017; Vol. August.
RevMan 2014 [Computer program]
    1. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
Roberts 2011
    1. Roberts CL, Ford JB, Algert CS, Antonsen S, Chalmers J, Cnattingius S, et al. Population‐based trends in pregnancy hypertension and pre‐eclampsia: an international comparative study. BMJ Open 2011;1(1):e000101. - PMC - PubMed
Ronsmans 2011
    1. Ronsmans C, Campbell O. Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy. BMC Public Health 2011;13(Suppl 3):S8. - PMC - PubMed
Sibai 2004
    1. Sibai BM. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstetrics & Gynecology 2004;103(5 Pt 1):981‐91. - PubMed
Sibai 2005
    1. Sibai BM. Diagnosis, prevention, and management of eclampsia. Obstetrics & Gynecology 2005;105(2):402‐10. - PubMed
Sibai 2007
    1. Sibai BM. Caring for women with hypertension in pregnancy. JAMA 2007;298(13):1548‐58. - PubMed
WHO 2009
    1. World Health Organization. Report on the World Health Organization Working Group on the Classification of Maternal Deaths and Severe Maternal Morbidities. Geneva: WHO, 2009.
WHO 2011
    1. World Health Organization. WHO Recommendations for Prevention and Treatment of Pre‐eclampsia and Eclampsia. Geneva: WHO, 2011. - PubMed
Xenakis 1997
    1. Xenakis EM, Piper JM, Field N, Conway D, Langer O. Preeclampsia: is induction of labor more successful?. Obstetrics & Gynecology 1997;89(4):600‐3. - PubMed

References to other published versions of this review

Amorim 2011
    1. Amorim MMR, Souza ASR, Katz L, Noronha Neto C. Planned caesarean section versus planned vaginal delivery for severe preeclampsia 2011. Cochrane Database of Systematic Reviews 2011, Issue 11. [DOI: 10.1002/14651858.CD009430] - DOI

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