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. 2017 Dec 21;62(1):e01923-17.
doi: 10.1128/AAC.01923-17. Print 2018 Jan.

Heteroresistance to Piperacillin-Tazobactam in Clinical Isolates of Escherichia coli Sequence Type 131

Ángel Rodríguez-Villodres  1 , José Manuel Ortiz de la Rosa  1 , Rocío Álvarez-Marín  1 , Jerónimo Pachón  1   2 , Javier Aznar  1   3 , José Antonio Lepe  1 , Younes Smani  4
Affiliations

Heteroresistance to Piperacillin-Tazobactam in Clinical Isolates of Escherichia coli Sequence Type 131

Ángel Rodríguez-Villodres et al. Antimicrob Agents Chemother. .
No abstract available

Keywords: Escherichia coli; ST131; heteroresistance; piperacillin-tazobactam.

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Figures

FIG 1
FIG 1
Etests with piperacillin-tazobactam (TZP) of isolate C2-23 with a 0.5 McFarland standard inoculum (a) and isolate C1-140 with 0.5 (b) and 2 (c) McFarland standard inocula. Colonies growing in the inner inhibition zone are characteristic of heteroresistance.
FIG 2
FIG 2
PAP of isolates C2-23 and C1-140 when 0.5 and 2 McFarland standard inocula are used. MICs and NICs are shown. A MIC/NIC ratio of >8 defines the population as heteroresistant to the antibiotic, a MIC/NIC ratio of >2 and ≤8 defines it as intermediately heteroresistant, and a MIC/NIC ratio of ≤2 defines it as homogeneously resistant. O.D., optical density.
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