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Review
. 2017:2017:2823671.
doi: 10.1155/2017/2823671. Epub 2017 Sep 14.

Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus

Ceren Eyileten  1 , Agnieszka Kaplon-Cieslicka  2 , Dagmara Mirowska-Guzel  1 , Lukasz Malek  3 , Marek Postula  1
Affiliations
Review

Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus

Ceren Eyileten et al. J Diabetes Res. 2017.

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in the central nervous system, and systemic or peripheral inflammatory conditions, such as acute coronary syndrome and type 2 diabetes mellitus (T2DM). BDNF is also expressed in several nonneuronal tissues, and platelets are the major source of peripheral BDNF. Here, we reviewed the potential role of BDNF in platelet reactivity in T2DM and its association with selected inflammatory and platelet activation mediators. Besides that, we focused on adipocytokines such as leptin, resistin, and adiponectin which are considered to take part in inflammation and both lipid and glucose metabolism in diabetic patients as previous studies showed the relation between adipocytokines and BDNF. We also reviewed the evidences of the antidiabetic effect of BDNF and the association with circulating inflammatory cytokines in T2DM.

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Figures

Figure 1
Figure 1
Brain-derived neurotrophic factor (BDNF) and its role on glucose haemostasis and potential relation with inflammation and type 2 diabetes mellitus (T2DM). MC4-R: melanocortin 4 receptor; TrkB: tropomyosin receptor kinase B; IL-6: interleukin 6; TNF-α: tumor necrosis factor alpha; CRP: c-reactive protein; PBMC: peripheral blood mononuclear cell.
See this image and copyright information in PMC

References

    1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009;32(Supplement 1):S62–S67. doi: 10.2337/dc09-S062. - DOI - PMC - PubMed
    1. Lontchi-Yimagou E., Sobngwi E., Matsha T. E., Kengne A. P. Diabetes mellitus and inflammation. Current Diabetes Reports. 2013;13(3):435–444. doi: 10.1007/s11892-013-0375-y. - DOI - PubMed
    1. Mattson M. P., Maudsley S., Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends in Neurosciences. 2004;27:589–594. doi: 10.1016/j.tins.2004.08.001. - DOI - PubMed
    1. Cohen-Cory S., Kidane A. H., Shirkey N. J., Marshak S. Brain-derived neurotrophic factor and the development of structural neuronal connectivity. Developmental Neurobiology. 2010;70:271–288. doi: 10.1002/dneu.20774. - DOI - PMC - PubMed
    1. Mirowska-Guzel D. The role of neurotrophic factors in the pathology and treatment of multiple sclerosis. Immunopharmacology and Immunotoxicology. 2009;31(1):32–38. doi: 10.1080/08923970802379819. - DOI - PubMed

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