Keeping in Touch to Differentiate
- PMID: 29065300
- DOI: 10.1016/j.devcel.2017.10.006
Keeping in Touch to Differentiate
Abstract
During zebrafish gastrulation, mesendoderm progenitor cells differentiate to mesoderm or endoderm cells. In this issue of Developmental Cell, Barone and colleagues (2017) show that the interplay between cell-cell contact duration and morphogen signaling can control this fate segregation, providing a new framework for self-organization in embryonic patterning.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate.Dev Cell. 2017 Oct 23;43(2):198-211.e12. doi: 10.1016/j.devcel.2017.09.014. Epub 2017 Oct 12. Dev Cell. 2017. PMID: 29033362
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