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Comment
. 2017 Nov;95(10):862-863.
doi: 10.1038/icb.2017.75. Epub 2017 Oct 24.

Embracing diversity gives antibodies the power to bind

Henry J Sutton  1 , Marion Pepper  2 , Ian A Cockburn  1
Affiliations
Comment

Embracing diversity gives antibodies the power to bind

Henry J Sutton et al. Immunol Cell Biol. 2017 Nov.
No abstract available

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Different modes of LAIR1 insertion to create Plasmodium-specific antibodies. LAIR1 sequences can be inserted into antibodies either at the site of VDJ joining to create an additional binding loop (a), or into the switch μ region either creating a bi-specific antibody with an additional binding loop (b), or creating a truncated single-chain Camel-like antibody (c). Adapted from Pieper at el.
See this image and copyright information in PMC

Comment on

  • Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
    Pieper K, Tan J, Piccoli L, Foglierini M, Barbieri S, Chen Y, Silacci-Fregni C, Wolf T, Jarrossay D, Anderle M, Abdi A, Ndungu FM, Doumbo OK, Traore B, Tran TM, Jongo S, Zenklusen I, Crompton PD, Daubenberger C, Bull PC, Sallusto F, Lanzavecchia A. Pieper K, et al. Nature. 2017 Aug 31;548(7669):597-601. doi: 10.1038/nature23670. Epub 2017 Aug 23. Nature. 2017. PMID: 28847005 Free PMC article.

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