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Case Reports
. 2017 Aug 23;9(8):e1596.
doi: 10.7759/cureus.1596.

Familial Multiple Trichodiscomas: Case Report and Concise Review

Yun Tong  1 , Alvin B Coda  2 , Jeremy A Schneider  1 , Tissa R Hata  1 , Philip R Cohen  3
Affiliations
Case Reports

Familial Multiple Trichodiscomas: Case Report and Concise Review

Yun Tong et al. Cureus. .

Abstract

Familial multiple trichodiscomas is a condition characterized by multiple asymptomatic skin papules. The inheritance pattern has not been established. The skin lesions usually appear in childhood. The diagnosis of the cutaneous papules is established by pathologic evaluation. Birt-Hogg-Dubé syndrome is excluded by not detecting any aberration in the folliculin gene locus. Including our patient, 15 index individuals and their families are described. There is no systemic organ involvement or associated malignancies in individuals with this condition.

Keywords: cancer; discoid; familial; fibromas; folliculin; irt-hogg-dubé; multiple; papules; trichodiscoma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Familial multiple trichodiscoma-associated trichodiscomas.
Distant (A, B, C) and closer (D) views of trichodiscomas presenting as numerous 2-4 mm whitish papules on the left (A) and right (B) posterior aspect of the ears (arrows) and the right side of the upper back (lesions present within the areas circled in purple, C and D) of a 39-year-old man.
Figure 2
Figure 2. Histopathology of familial multiple trichodiscoma-associated trichodiscoma.
A punch biopsy of the trichodiscoma on the right side of the upper back of a 39-year-old man shows a dome-shaped papule in the center of the specimen which extends from an underlying hair follicle with an associated sebaceous gland; the three arrows demarcate the inferior border of the dermal papule (A and B). The overlying epidermis is flattened and the elongated epithelial rete ridges extend around the borders of the dermal tumor (A and B). Collagen deposition is increased around the blood vessels in the dermis (B and C); representative increased collagen fibers are demonstrated by arrows (C). The fibroblasts in the dermis are also increased (C). Mucin is increased in the dermal stroma (B and D); the mucin appears blue after tissue sections are stained with colloidal iron (D) [hematoxylin and eosin: A, x4; B, x10; C, x20; colloidal iron: D, x10].
See this image and copyright information in PMC

References

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    1. Birt-Hogg-Dubé syndrome: a review of dermatological manifestations and other symptoms. Tong Y, Schneider JA, Coda AB, et al. Am J Clin Dermatol. 2017:1–15. - PubMed
    1. Starink TM, Kisch LS, Meijer CJ. Arch Dermatol. Vol. 121. Jul: 1985. Familial multiple trichodiscomas. A clinicopathologic study; pp. 888–891. - PubMed
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