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Review
. 2017 Aug 23;9(8):e1598.
doi: 10.7759/cureus.1598.

Pathogenesis of Drug Induced Non-Allergic Angioedema: A Review of Unusual Etiologies

Junior Kalambay  1 , Haider Ghazanfar  2 , Karen A Martes Pena  2 , Ruhul A Munshi  3 , George Zhang  4 , Jay Y Patel  5
Affiliations
Review

Pathogenesis of Drug Induced Non-Allergic Angioedema: A Review of Unusual Etiologies

Junior Kalambay et al. Cureus. .

Abstract

Angioedema is the swelling of mucosal and sub-mucosal tissue. Typically, it manifests as the swelling of the face, lips, and tongue. Angioedema can be severe and life threatening when it involves the respiratory tract. Drug induced allergic angioedema and drug induced non-allergic angioedema differ in their mediator, their clinical presentations, and their management. In drug induced non-allergic angioedema, symptoms are resistant to antihistamine and corticosteroid treatment. The aim of the analysis was to identify which medications are associated with drug-induced non-allergic angioedema and to understand the mechanism of action via which of these medication cause angioedema.

Keywords: angioedema; causality; drug hypersensitivity; drug induced reactions; female; hereditary angioedema; hypersensitivity; non-allergic; urticarial.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Interaction of kallikrein-kiting system (KKS), renin angiotensin aldosterone system (RAAS) and complement system in the development of angioedema
See this image and copyright information in PMC

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