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Review
. 2016 Aug 16:5:42-45.
doi: 10.1016/j.jcte.2016.08.001. eCollection 2016 Sep.

Hypogonadism in thalassemia major patients

Sasima Srisukh  1 , Boonsong Ongphiphadhanakul  1 , Pongamorn Bunnag  1
Affiliations
Review

Hypogonadism in thalassemia major patients

Sasima Srisukh et al. J Clin Transl Endocrinol. .

Abstract

Despite recent advances in iron chelation therapy, excess iron deposition in pituitary gonadotropic cells remains one of the major problems in thalassemic patients. Hypogonadism, mostly hypogonadotropic hypogonadism, is usually detected during puberty. Early diagnosis and treatment are crucial for normal pubertal development and to reduce the complications of hypogonadism. The risks and benefits of hormonal replacement therapy, especially regarding the thromboembolic event, remain a challenge for providers caring for thalassemic patients.

Keywords: Hypogonadism; Thalassemia.

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