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Case Reports
. 2017 Oct;22(42):17-00659.
doi: 10.2807/1560-7917.ES.2017.22.42.17-00659.

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

David Terkelsen  1   2 , Jacob Tolstrup  2   3 , Camilla Hundahl Johnsen  4 , Ole Lund  4 , Helle Kiellberg Larsen  3 , Peder Worning  1 , Magnus Unemo  5   6 , Henrik Westh  1   7   6
Affiliations
Case Reports

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

David Terkelsen et al. Euro Surveill. 2017 Oct.

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

Keywords: Neisseria gonorrhoeae; Resfinder; STD; antibiotic; multidrug-resistant; treatment.

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Conflict of interest statement

Conflict of interest: None declared.

References

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