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. 2017 Oct 24;125(10):104502.
doi: 10.1289/EHP2820.

Online Serum PFOA Calculator for Adults

Scott M Bartell  1   2   3
Affiliations

Online Serum PFOA Calculator for Adults

Scott M Bartell. Environ Health Perspect. .

Abstract

Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that has been detected in >100 public water systems in the United States alone. A variety of epidemiological investigations of PFOA have been published, mostly using measured or modeled serum PFOA concentrations as the exposure metric. Comparison of drinking water PFOA concentrations to those study findings or to typical serum concentrations requires pharmacokinetic modeling. This brief communication describes an online Javascript calculator that easily plots the expected serum PFOA concentration over time and at steady state for adults after starting or stopping consumption of PFOA-contaminated water. Two examples of usage are provided, including increasing serum PFOA after ongoing consumption of contaminated water at the federal limit, and decreasing serum PFOA after carbon filtration began in a contaminated water system. https://doi.org/10.1289/EHP2820.

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Figures

Input form.
Figure 1.
Input form for online serum PFOA calculator.
Line graph plotting serum PFOA in nanograms per milliliter (y-axis) across time in years (x-axis), where serum prediction is 9.67. Starting serum PFOA concentration is 2.08 nanograms per milliliter. Water PFOA concentration is 70 parts per trillion. Serum PFOA concentration from other ongoing exposures is 2.08 nanograms per milliliter. Half-life of PFOA in serum is 2.3 years. Steady-state ratio for serum is to water concentrations is 114. Predicted steady-state serum PFOA concentration is 10.06 nanograms per milliliter.
Figure 2.
Predicted serum concentration over time from online serum PFOA calculator.
See this image and copyright information in PMC

References

    1. ATSDR (Agency for Toxic Substances and Disease Registry). 2015. Draft Toxicological Profile for Perfluoroalkyls. Atlanta, GA:Centers for Disease Control and Prevention. https://www.atsdr.cdc.gov/toxprofiles/tp200.pdf [accessed 3 September 2017].
    1. Bagenstose K. 2017. Ivyland woman sues Navy after finding high PFOA blood level. The Intelligencer. Doylestown, PA; 12 January 2017 http://www.theintell.com/news/horsham-pfos/ivyland-woman-sues-navy-after... [accessed 3 September 2017].
    1. Bartell SM. 2012. Bias in half-life estimates using log concentration regression in the presence of background exposures, and potential solutions. J Expo Sci Environ Epidemiol 22(3):299–303, PMID: 22333729, 10.1038/jes.2012.2. - DOI - PubMed
    1. Bartell SM, Calafat AM, Lyu C, Kato K, Ryan PB, Steenland K. 2010. Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia. Environ Health Perspect 118(2):222–228, PMID: 20123620, 10.1289/ehp.0901252. - DOI - PMC - PubMed
    1. Benbrahim-Tallaa L, Lauby-Secretan B, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, et al. 2014. Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone. Lancet Oncol 15(9):924–925, PMID: 25225686, 10.1016/S1470-2045(14)70316-X. - DOI - PubMed