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. 2017 Oct 25;4(4):78.
doi: 10.3390/medicines4040078.

Ameliorative Effect of Caffeic Acid on Capecitabine-Induced Hepatic and Renal Dysfunction: Involvement of the Antioxidant Defence System

Ebenezer Tunde Olayinka  1 , Olaniyi Solomon Ola  2 , Ayokanmi Ore  3 , Oluwatobi Adewumi Adeyemo  4
Affiliations

Ameliorative Effect of Caffeic Acid on Capecitabine-Induced Hepatic and Renal Dysfunction: Involvement of the Antioxidant Defence System

Ebenezer Tunde Olayinka et al. Medicines (Basel). .

Abstract

Background: It has been postulated that during liver and kidney damage there is a decreased in the antioxidant status associated with a simultaneous increase in the reactive oxygen species and lipid peroxidation. In consonant with this, Capecitabine, an oral chemotherapy and inactive non-cytotoxic fluoropyrimidine considered for the treatment of advance colorectal cancer, has also been shown to induce oxidative stress in liver tissues. Caffeic acid, a typical hydroxycinnamic, has been claimed to be effective against oxidative stress. Therefore, this present work studied the protective effect of caffeic acid on oxidative stress-induced liver and kidney damage by the administration of capecitabine. Methods: Twenty-four male Wistar strain rats were randomly divided into four treatment groups: A. control, B. capecitabine (CPTB)-treated group (30 mg/kg b.w. CPTB), C. caffeic acid (CFA)-treated group (100 mg/kg b.w. CFA) and D. co-treated group with CFA (100 mg/kg b.w.) and CPTB (30 mg/kg b.w.). Results: Caffeic acid administration significantly ameliorated the elevated plasma biomarkers of hepatic and renal tissue damage induced by the capecitabine and improved enzymatic and non-enzymatic antioxidant levels in liver organ. Conclusions: The protective effect of caffeic acid could be attributed to its ability to boost the antioxidant defence system and reduce lipid peroxidation.

Keywords: Caffeic acid; anti-oxidant; capecitabine; hepatoprotective; reactive oxygen species.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Caffeic acid.
Figure 2
Figure 2
Protective effect of caffeic acid on the reduction of glutathione peroxidase (GPx) levels in rats due to capecitabine-induced toxicity. Data are expressed as means ± SD for six rats in each group; * significantly different from the control (p < 0.05); ¥ significantly different from the capecitabine group (p < 0.05).
Figure 3
Figure 3
Influence of caffeic acid on capecitabine-induced changes in hepatic GST activity in rats. Data are expressed as means ± SD for six rats in each group; * significantly different from the control (p < 0.05); ¥ significantly different from the capecitabine group (p < 0.05).
Figure 4
Figure 4
Protective effect of caffeic acid on the reduction of hepatic ascorbic acid (vitamin C) levels in rats due to capecitabine-induced toxicity. Data are expressed as means ± SD for six rats in each group; * significantly different from the control (p < 0.05); ¥ significantly different from the capecitabine group (p < 0.05).
Figure 5
Figure 5
Protective effect of caffeic acid on the reduction of hepatic reduced glutathione (GSH) in rats due to capecitabine-induced toxicity. Data are expressed as means ± SD for six rats in each group; * significantly different from the control group (p < 0.05); ¥ significantly different from the capecitabine group (p < 0.05).
Figure 6
Figure 6
Protective effect of caffeic acid on the increase in lipid peroxidation (MDA) levels in rats due to capecitabine-induced toxicity. Data are expressed as means ± SD for six rats in each group; * significantly different from the control group (p < 0.05); ¥ significantly different from the capecitabine group (p < 0.05).
See this image and copyright information in PMC

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