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. 2017;42(7-8):423-445.
doi: 10.1080/87565641.2017.1374960. Epub 2017 Oct 25.

Genetic and environmental risk factors for developmental dyslexia in children: systematic review of the last decade

Natalia Becker  1 , Mailton Vasconcelos  2 , Vanessa Oliveira  2 , Fernanda Caroline Dos Santos  3 , Lisiane Bizarro  2 , Rosa M M De Almeida  2 , Jerusa Fumagalli De Salles  1 , Maria Raquel Santos Carvalho  3
Affiliations

Genetic and environmental risk factors for developmental dyslexia in children: systematic review of the last decade

Natalia Becker et al. Dev Neuropsychol. 2017.

Abstract

Despite advances in the characterization of developmental dyslexia (DD), several questions regarding the interplay between DD-susceptibility genes and environmental risk factors remain open. This systematic review aimed at answering the following questions: What has been the impact of new resources on the knowledge about DD? Which questions remain open? What is the investigative agenda for the short term? Forty-six studies were analyzed. Despite the growing literature on DD candidate genes, most studies have not been replicated. We found large effects on causative genes and smaller environmental contributions, involving maternal smoking during pregnancy, SES and the DYX1C1-1259C/G marker. Implications are discussed.

Keywords: Developmental dyslexia; environment; genes; molecular genetics; neurobiology; socioeconomic status.

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