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Editorial
. 2017 Nov;37(11):1990-1993.
doi: 10.1161/ATVBAHA.117.310177.

New Mouse Model of Abdominal Aortic Aneurysm: Put Out to Expand

Stoyan N Angelov  1 , Jay Zhu  1 , David A Dichek  2
Affiliations
Editorial

New Mouse Model of Abdominal Aortic Aneurysm: Put Out to Expand

Stoyan N Angelov et al. Arterioscler Thromb Vasc Biol. 2017 Nov.
No abstract available

Keywords: Editorials; aneurysm; angiotensin-converting enzyme inhibitors; aorta; aortic aneurysm, abdominal; transforming growth factor beta.

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Figures

Figure
Figure
Comparison of established and new mouse models of abdominal aortic aneurysm (AAA). A–B) Aorta from mouse treated with angiotensin II infusion and injection of anti-TGF-β antibodies. Aorta was removed after euthanasia. A) Segment of distal thoracic (Th) and proximal abdominal (Abd) aorta. * = contained hemorrhage. B) Section shows rupture of media without medial dilation, and containment of rupture by the adventitia (Adv). Arrows = free ends of ruptured media. C) Schematic of the new murine AAA model reported by Lareyre et al. Elastase is applied topically to the abdominal aorta, and mice are injected with anti-TGF-β antibodies. Aortas undergo medial degeneration with breaks in elastic laminae (arrows) as well as dilation that includes all 3 layers (intima, media, adventitia). Intraluminal thrombus (arrowhead) is common, as is rupture of all 3 layers of the aorta (*), which is typically fatal. A) Aorta explanted after saline perfusion. B) Hematoxylin and eosin stain of aortic section; illuminated with fluorescein wavelengths. Size bars: A) 1 mm; B) 500 µm.
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Comment on

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