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Case Reports
. 2017 Oct 26:18:1140-1144.
doi: 10.12659/ajcr.905905.

Asymptomatic Meningitis and Lung Cavity in a Case of Cryptococcosis

Aixin Li  1 , Qunhui Li  1 , Caiping Guo  1 , Yulin Zhang  1
Affiliations
Case Reports

Asymptomatic Meningitis and Lung Cavity in a Case of Cryptococcosis

Aixin Li et al. Am J Case Rep. .

Abstract

BACKGROUND Cryptococcus neoformans (C. neoformans) infection is one of the most common opportunistic infections in AIDS patients. C. neoformans usually infects the central nervous system (CNS) and/or lungs with typical clinical manifestation. CASE REPORT Here, we report the case of a 52-year-old HIV-1-infected man with disseminated cryptococcosis, including subacute meningitis, pulmonary, and cutaneous cryptococcosis, but only skin lesion served as the chief complaint. Moreover, the results of cerebrospinal fluid (CSF) tests and lung computed tomography (CT) scan were atypical. CONCLUSIONS We present the clinical characteristics of this case and discuss the diagnostic procedure, which will likely help clinicians in making a timely definitive diagnosis of this disease.

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Conflict of interest statement

Conflict of interest: None declared

Conflict of interest

None.

Figures

Figure 1.
Figure 1.
Morphological presentation of this case. (A) Cryptococcosis skin lesion. (B) Pathological morphology of the cutaneous biopsy. Cryptococcus neoformans yeasts with clear mucoid capsule are present amid the background spindle cell proliferation. (C) Cerebrospinal fluid light India ink staining. (D) Normal bronchial mucosa. (E) Cryptococcosis skin lesion after 20 days of anti-C. neoformans treatment. (F) Cryptococcosis skin lesion after 40 days of anti-C. neoformans treatment.
Figure 2.
Figure 2.
Thoracic CT scans of this case. Column denotes different parts of the lungs (lung window and mediastinal window) and row denotes different scan time. From I to L, the scan interval was about 15 days.
See this image and copyright information in PMC

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References

    1. Sabiiti W, Robertson E, Beale MA, et al. Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis. J Clin Invest. 2014;124:2000–8. - PMC - PubMed
    1. Foong KS, Lee A, Vasquez G. Cryptococcal infection of the ventriculoperitoneal shunt in an immunocompetent patient. Am J Case Rep. 2016;17:31–34. - PMC - PubMed
    1. Tintelnot K, de Hoog GS, Haase G. [Fungal infections of the central nervous system in the immunocompetent host] Pathologe. 2013;34:534–39. [in German] - PubMed
    1. Mihret W, Zenebe G, Bekele A, et al. Chronic meningitis in immunocompromised adult Ethiopians visiting Tikur Anbessa Teaching Hospital and Ye’huleshet Clinic from 2003–2004. Ethiop Med J. 2014;(Suppl 1):43–48. - PubMed
    1. Park BJ, Wannemuehler KA, Marston BJ, et al. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS. 2009;23:525–30. - PubMed

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