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. 2017 Oct 21:12:308-322.
doi: 10.1515/med-2017-0045. eCollection 2017.

Cell Based Therapeutic Approach in Vascular Surgery: Application and Review

Aldo Rocca  1 , Domenico Tafuri  2 , Marianna Paccone  3 , Antonio Giuliani  4 , Anna Ginevra Immacolata Zamboli  5 , Giuseppe Surfaro  6 , Andrea Paccone  3 , Rita Compagna  7 , Maurizo Amato  7 , Raffaele Serra  8 , Bruno Amato  7
Affiliations

Cell Based Therapeutic Approach in Vascular Surgery: Application and Review

Aldo Rocca et al. Open Med (Wars). .

Abstract

Multipotent stem cells - such as mesenchymal stem/stromal cells and stem cells derived from different sources like vascular wall are intensely studied to try to rapidly translate their discovered features from bench to bedside. Vascular wall resident stem cells recruitment, differentiation, survival, proliferation, growth factor production, and signaling pathways transduced were analyzed. We studied biological properties of vascular resident stem cells and explored the relationship from several factors as Matrix Metalloproteinases (MMPs) and regulations of biological, translational and clinical features of these cells. In this review we described a translational and clinical approach to Adult Vascular Wall Resident Multipotent Vascular Stem Cells (VW-SCs) and reported their involvement in alternative clinical approach as cells based therapy in vascular disease like arterial aneurysms or peripheral arterial obstructive disease.

Keywords: Arterial aneurysms; Cell-based Therapy; Multipotent Stem Cells; Peripheral arterial obstructive disease; Vascular Progenitors; Vascular Surgery.

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Conflict of interest statement

Conflict of interest statement: Authors state no conflict of interest

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