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. 2017 Oct 21:12:308-322.
doi: 10.1515/med-2017-0045. eCollection 2017.

Cell Based Therapeutic Approach in Vascular Surgery: Application and Review

Aldo Rocca  1 , Domenico Tafuri  2 , Marianna Paccone  3 , Antonio Giuliani  4 , Anna Ginevra Immacolata Zamboli  5 , Giuseppe Surfaro  6 , Andrea Paccone  3 , Rita Compagna  7 , Maurizo Amato  7 , Raffaele Serra  8 , Bruno Amato  7
Affiliations

Cell Based Therapeutic Approach in Vascular Surgery: Application and Review

Aldo Rocca et al. Open Med (Wars). .

Abstract

Multipotent stem cells - such as mesenchymal stem/stromal cells and stem cells derived from different sources like vascular wall are intensely studied to try to rapidly translate their discovered features from bench to bedside. Vascular wall resident stem cells recruitment, differentiation, survival, proliferation, growth factor production, and signaling pathways transduced were analyzed. We studied biological properties of vascular resident stem cells and explored the relationship from several factors as Matrix Metalloproteinases (MMPs) and regulations of biological, translational and clinical features of these cells. In this review we described a translational and clinical approach to Adult Vascular Wall Resident Multipotent Vascular Stem Cells (VW-SCs) and reported their involvement in alternative clinical approach as cells based therapy in vascular disease like arterial aneurysms or peripheral arterial obstructive disease.

Keywords: Arterial aneurysms; Cell-based Therapy; Multipotent Stem Cells; Peripheral arterial obstructive disease; Vascular Progenitors; Vascular Surgery.

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Conflict of interest statement

Conflict of interest statement: Authors state no conflict of interest

References

    1. Pacilli A., Pasquinelli G.. Vascular wall resident progenitor cells. A review. Experimental Cell Research. 2009;315(6):901–914. - PubMed
    1. Käßmeyer S., Plendl J., Custodis P., Bahramsoltani M.. New insights in vascular development: vasculogenesis and endothelial progenitor cells. Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia. 2009;38(1):1–11. - PubMed
    1. Ergün S., Tilki D., Hohn H.P., Gehling U., Kilic N.. Potential implications of vascular wall resident endothelial progenitor cells. Thrombosis and Haemostasis. 2007;98(5):930–939. - PubMed
    1. Serra R., G. Buffone G., Costanzo G., Montemurro R., Scarcello E., Stillitano DM.. et al. Altered metalloproteinase-9 expression as least common denominator between varicocele, inguinal hernia, and chronic venous disorders. Annals of Vascular Surgery. 2014;28(3):705–709. - PubMed
    1. Barnett J.M., McCollum G.W., Fowler J.A., Duan J.J., Kay J.D., Liu R.Q., Bingaman D.P., Penn J.S.. Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR. Investigative Ophthalmology and Visual Science. 2007;48(2):907–915. - PMC - PubMed

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