All for One, and One for All
- PMID: 29073370
- DOI: 10.1016/j.cels.2017.10.005
All for One, and One for All
Abstract
Hemizygous deletion of a gene in tumor cells frequently causes reduced expression of its encoded mRNA and protein, as well as reduced protein-but not mRNA-expression of other members in the same protein complex.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.Cell Syst. 2017 Oct 25;5(4):399-409.e5. doi: 10.1016/j.cels.2017.09.011. Epub 2017 Oct 11. Cell Syst. 2017. PMID: 29032073 Free PMC article.
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Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer.Cell Syst. 2017 Oct 25;5(4):386-398.e4. doi: 10.1016/j.cels.2017.08.013. Epub 2017 Oct 11. Cell Syst. 2017. PMID: 29032074 Free PMC article.
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