Computing at the Front-End by Receptor Networks

Affiliations

¹ Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), 48080 Bilbao, Spain; IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain. Electronic address: j.vilar@ikerbasque.org.
² Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA. Electronic address: lsaiz@ucdavis.edu.

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Comment

Jose M G Vilar et al. Cell Syst. 2017.

Free article

. 2017 Oct 25;5(4):316-318.

doi: 10.1016/j.cels.2017.10.006.

¹ Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), 48080 Bilbao, Spain; IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain. Electronic address: j.vilar@ikerbasque.org.
² Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA. Electronic address: lsaiz@ucdavis.edu.

Abstract

Cells use receptors at their surface not just to transduce signals but also to perform computations before relaying them downstream.

Combinatorial Signal Perception in the BMP Pathway.
Antebi YE, Linton JM, Klumpe H, Bintu B, Gong M, Su C, McCardell R, Elowitz MB. Antebi YE, et al. Cell. 2017 Sep 7;170(6):1184-1196.e24. doi: 10.1016/j.cell.2017.08.015. Cell. 2017. PMID: 28886385 Free PMC article.