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. 2018 Jan:124:103-107.
doi: 10.1016/j.fitote.2017.10.013. Epub 2017 Oct 23.

Phochrodines A-D, first naturally occurring new chromenopyridines from mangrove entophytic fungus Phomopsis sp. 33

Huiping Chen  1 , Meixiang Huang  1 , Xuewen Li  1 , Lan Liu  2 , Bin Chen  3 , Jun Wang  4 , Yongcheng Lin  5
Affiliations

Phochrodines A-D, first naturally occurring new chromenopyridines from mangrove entophytic fungus Phomopsis sp. 33

Huiping Chen et al. Fitoterapia. 2018 Jan.

Abstract

Four new chromenopyridine derivatives, phochrodines A-D (1-4), were identified from mangrove entophytic fungus Phomopsis sp. 33# by means of various modern chromatographic, spectroscopic and single crystal X-ray diffraction techniques. Compounds 1-4 with an unusual 5H-chromeno[4,3-b]pyridine skeleton were the first naturally occurring chromenopyridines. Their anti-inflammatory, antioxidant and cytotoxic activities were evaluated. 3 and 4 showed moderate inhibition of nitric oxide production with IC50 values of 49.0 as well as 51.0μM, respectively. 4 had well ability to scavenge DPPH radical with IC50 value of 34.0μM. The four had no cytotoxic activity for MDA-MB-435 breast cancer cells.

Keywords: Mangrove endophytic fungus; Natural chromenopyridine; Phomopsis sp. 33#.

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