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Review
. 2018 Mar:113:20-25.
doi: 10.1016/j.urology.2017.10.017. Epub 2017 Oct 23.

Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication

Alexandre Leme Godoy-Santos  1 , Homero Bruschini  2 , Jose Cury  2 , Miguel Srougi  2 , Cesar de Cesar-Netto  3 , Lucas F Fonseca  3 , Nicola Maffulli  4
Affiliations
Review

Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication

Alexandre Leme Godoy-Santos et al. Urology. 2018 Mar.

Abstract

Objective: To evaluate the current evidence and to identify associated risk factors that increase the incidence of this complication. Fluoroquinolone (FQ) has been considered the first-line therapy for uncomplicated urinary infections. FQ has been associated with Achilles tendon disorders, especially during the first month of treatment.

Methods: Data sources searched included PubMed, MEDLINE, and Scopus from January 1988 to June 2017.

Results: A total of 79 articles were used, with ciprofloxacin representing the most common drug.

Conclusion: We found that male gender, advanced age, normal body mass index, chronic renal failure, and concurrent use of corticosteroids increase the risk of Achilles tendon disorders.

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