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. 1988 Oct;40(10):743-5.
doi: 10.1111/j.2042-7158.1988.tb07010.x.

Prostaglandin synthetase inhibitors in feverfew

W J Pugh  1 , K Sambo
Affiliations

Prostaglandin synthetase inhibitors in feverfew

W J Pugh et al. J Pharm Pharmacol. 1988 Oct.

Abstract

The IC50 values for the in-vitro inhibition of the prostaglandin synthetase (bovine seminal vesicle mitochondrial fraction) mediated PGE2 production from arachidonic acid by parthenolide, michefuscalide and chrysanthenyl acetate were 11.0 +/- 0.44, 12.1 +/- 0.51 and 14.2 +/- 0.58 microM (mean +/- 95% confidence limits), respectively.

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