Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov;7(5):738-746.
doi: 10.3892/mco.2017.1399. Epub 2017 Aug 28.

Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment

Meijia Wu  1 , Shengwu Huang  1
Affiliations

Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment

Meijia Wu et al. Mol Clin Oncol. 2017 Nov.

Abstract

In recent years, magnetic nanoparticles (MNPs) have demonstrated marked progress in the field of oncology. General nanoparticles are widely used in tumor targeting, and the intrinsic magnetic property of MNPs makes them the most promising nanomaterial to be used as contrast agents for magnetic resonance imaging (MRI) and induced magnetic hyperthermia. The properties of MNPs are fully exploited when they are used as drug delivery agents, wherein drugs may be targeted to the desired specific location in vivo by application of an external magnetic field. Early diagnosis of cancer may be achieved by MRI, therefore, individualized treatment may be combined with MRI, so as to achieve the precise definition and appropriate treatment. In the present review, research on MNPs in cancer diagnosis, drug delivery and treatment has been summarized. Furthermore, the future perspectives and challenges of MNPs in the field of oncology are also discussed.

Keywords: cancer; cancer diagnosis; drug delivery; magnetic nanoparticles; treatment.

PubMed Disclaimer

References

    1. Yarar E, Karakas G, Rende D, Ozisik R, Malta S. Influence of surface coating of magnetic nanoparticles on mechanical properties of polymer nanocomposites. Journal. 2016
    1. Briguet A, Jeandey C, Tournier E. System of coils for producing additional fields for obtaining polarization fields with constant gradients in a magnet having polarization pole pieces for image production by nuclear magnetic resonance. Journal. 1988
    1. Dan M, Bae Y, Pittman TA, Yokel RA. Alternating magnetic field-induced hyperthermia increases iron oxide nanoparticle cell association/uptake and flux in blood-brain barrier models. Pharm Res. 2015;32:1615–1625. doi: 10.1007/s11095-014-1561-6. - DOI - PMC - PubMed
    1. Rosenberger I, Strauss A, Dobiasch S, Weis C, Szanyi S, Gil-Iceta L, Alonso E, Esparza González M, Gómez-Vallejo V, Szczupak B, et al. Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer. J Control Release. 2015;214:76–84. doi: 10.1016/j.jconrel.2015.07.017. - DOI - PubMed
    1. Lu AH, Zhang XQ, Sun Q, Zhang Y, Song Q, Schüth F, Chen C, Cheng F. Precise synthesis of discrete and dispersible carbon-protected magnetic nanoparticles for efficient magnetic resonance imaging and photothermal therapy. Nano Res. 2016;9:1460–1469. doi: 10.1007/s12274-016-1042-9. - DOI

LinkOut - more resources