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. 2017 Sep 5;7(10):e00803.
doi: 10.1002/brb3.803. eCollection 2017 Oct.

Increased prevalence of celiac disease in idiopathic inflammatory myopathies

Olof Danielsson  1   2 , Björn Lindvall  3 , Claes Hallert  4   5 , Magnus Vrethem  1   2   6 , Charlotte Dahle  2   7
Affiliations

Increased prevalence of celiac disease in idiopathic inflammatory myopathies

Olof Danielsson et al. Brain Behav. .

Abstract

Objectives: Idiopathic inflammatory myopathies (IIM) are often associated with other immune-mediated diseases or malignancy. Some studies have reported a high frequency of celiac disease in IIM. The aim of this study was to investigate the prevalence of celiac disease, systemic inflammatory diseases, and malignancy in a cohort of IIM patients, and estimate the incidence of IIM in the county of Östergötland, Sweden.

Material and methods: We reviewed medical records and analyzed sera from 106 patients, fulfilling pathological criteria of inflammatory myopathy, for the presence of IgA antibodies against endomysium and gliadin. Antibody-positive patients were offered further investigation with small bowel biopsy or investigation for the presence of antibodies against antitissue transglutaminase (t-TG). The patients were classified according to Bohan and Peter or Griggs criteria. The presence of celiac disease, systemic inflammatory, and malignant diseases was documented.

Results: Four of 88 patients classified as IIM (4.5%) had biopsy-confirmed celiac disease, which is higher than the prevalence in the general population, detected with a similar screening procedure (0.53%). Thirty-three patients (38%) had a systemic inflammatory disease and five (5.7%) a malignancy. The incidence of confirmed IIM in the county of Östergötland was 7.3 per million/year.

Conclusions: The results highlight the high frequency of associated inflammatory and malignant diseases and confirm an increased prevalence of celiac disease in IIM.

Keywords: celiac disease; idiopathic inflammatory myopathies; incidence; myositis; prevalence.

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Figures

Figure 1
Figure 1
The number of IIM patients in the respective diagnostic group is shown
Figure 2
Figure 2
The distribution of patients with systemic inflammatory diseases is shown by the number of cases with the respective diagnosis. *Three of 18 patients with IBM and concomitant Sjögren syndrome are also included. Abbreviation: Antisynth. = Antisynthetase
See this image and copyright information in PMC

References

    1. Agresti, A. , & Coull, B. A. (1998). Approximate is better than “exact” for interval estimation of binominal proportions. The American Statistician, 52(2), 119–126.
    1. Arahata, K. , & Engel, A. G. (1984). Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Annals of Neurology, 16, 193–208. - PubMed
    1. Badrising, U. A. , Schreuder, G. M. , Giphart, M. J. , Geleijns, K. , Verschuuren, J. J. , Wintzen, A. R. , … Dutch, I. B. M. Study Group . (2004). Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis. Neurology, 63, 2396–2398. - PubMed
    1. Bergua, C. , Chiavelli, H. , Simon, J. P. , Boyer, O. , Jouen, F. , Stenzel, W. , & Martinet, J. (2016). Immune‐mediated necrotizing myopathy. Zeitschrift fur Rheumatologie, 75, 151–156. - PubMed
    1. Bohan, A. , & Peter, J. B. (1975). Polymyositis and dermatomyositis (first of two parts). The New England Journal of Medicine, 292, 344–347. - PubMed

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