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Randomized Controlled Trial
. 2017 Dec;117(12):2587-2600.
doi: 10.1007/s00421-017-3746-2. Epub 2017 Oct 26.

Concomitant external pneumatic compression treatment with consecutive days of high intensity interval training reduces markers of proteolysis

Cody T Haun  1 , Michael D Roberts  1   2 , Matthew A Romero  1 , Shelby C Osburn  1 , James C Healy  2 , Angelique N Moore  2   3 , Christopher B Mobley  1 , Paul A Roberson  1 , Wesley C Kephart  1 , Petey W Mumford  1 , Michael D Goodlett  2   4 , David D Pascoe  1 , Jeffrey S Martin  5   6
Affiliations
Randomized Controlled Trial

Concomitant external pneumatic compression treatment with consecutive days of high intensity interval training reduces markers of proteolysis

Cody T Haun et al. Eur J Appl Physiol. 2017 Dec.

Abstract

Purpose: To compare the effects of external pneumatic compression (EPC) and sham when used concurrently with high intensity interval training (HIIT) on performance-related outcomes and recovery-related molecular measures.

Methods: Eighteen recreationally endurance-trained male participants (age: 21.6 ± 2.4 years, BMI: 25.7 ± 0.5 kg/m2, VO2peak: 51.3 ± 0.9 mL/kg/min) were randomized to balanced sham and EPC treatment groups. Three consecutive days of HIIT followed by EPC/sham treatment (Days 2-4) and 3 consecutive days of recovery (Days 5-7) with EPC/sham only on Days 5-6 were employed. Venipuncture, flexibility and pressure-to-pain threshold (PPT) measurements were made throughout. Vastus lateralis muscle was biopsied at PRE (i.e., Day 1), 1-h post-EPC/sham treatment on Day 2 (POST1), and 24-h post-EPC/sham treatment on Day 7 (POST2). 6-km run time trial performance was tested at PRE and POST2.

Results: No group × time interaction was observed for flexibility, PPT, or serum measures of creatine kinase (CK), hsCRP, and 8-isoprostane. However, there was a main effect of time for serum CK (p = 0.005). Change from PRE in 6-km run times at POST2 were not significantly different between groups. Significant between-groups differences existed for change from PRE in atrogin-1 mRNA (p = 0.018) at the POST1 time point (EPC: - 19.7 ± 8.1%, sham: + 7.7 ± 5.9%) and atrogin-1 protein concentration (p = 0.013) at the POST2 time point (EPC: - 31.8 ± 7.5%, sham: + 96.0 ± 34.7%). In addition, change from PRE in poly-Ub proteins was significantly different between groups at both the POST1 (EPC: - 26.0 ± 10.3%, sham: + 34.8 ± 28.5%; p = 0.046) and POST2 (EPC: - 33.7 ± 17.2%, sham: + 21.4 ± 14.9%; p = 0.037) time points.

Conclusions: EPC when used concurrently with HIIT and in subsequent recovery days reduces skeletal muscle markers of proteolysis.

Keywords: Endurance exercise; High intensity interval training; Oxidative stress; Pneumatic compression; Proteolysis; Recovery; Skeletal muscle.

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